Abstract: A 6-aminopyrazolopyrimidine compound, or a pharmaceutically acceptable salt thereof, having NLRP3 inflammasome inhibitory activity, a pharmaceutical composition comprising the same, and their medical use, etc., are provided. A compound of Formula [IA]: or a pharmaceutically acceptable salt thereof, wherein a partial structure: is a structure of the following formula: etc. wherein R4 is hydrogen or C1-4 alkyl, in which the alkyl may be optionally substituted with hydroxy or cyano, Ring group CyA is a group of the following formula: etc. wherein R6 and R7 are, each independently, hydrogen, hydroxy, cyano, C1-6 alkyl, etc., R8 and R9 are, each independently, hydrogen, C1-4 alkyl, or C1-4 haloalkyl, R10 is hydrogen, cyano, C1-6 alkyl, etc.), R1 is hydrogen or C1-4 alkyl, R2A and R3A are, each independently, hydrogen, C1-6 alkyl etc.

Abstract: An acylsulfamide compound, or a pharmaceutically acceptable salt thereof, having NLRP3 inflammasome inhibitory activity, a pharmaceutical composition comprising the same, and their medical use, etc., are provided. A compound of Formula [Ia]: or a pharmaceutically acceptable salt thereof, wherein a partial structure: is: Ring Cy is an optionally substituted heteroaryl or phenyl; RDy and REy are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-4 haloalkyl, optionally substituted C3-6 cycloalkyl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl, or alternatively, RDy and REy may combine together with the nitrogen atom to which they attach to form heterocycloalkyl, etc.

Abstract: The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.