Abstract: The inventors found that B cell activation is suppressed by TGF-?3 produced by LAG3+ Treg. They also discovered a B cell activation suppressor which contains TGF-?3 or a molecule having a TGF-?3 function, and a therapeutic agent for autoimmune diseases.

Abstract: A music apparatus is provided with a memory device that stores waveform data, and a sound device that has a plurality of tone generating channels, each of which is tuned in normal setting effective to process the waveform data retrieved from the memory device so as to generate a musical sound. An input device is placed in either of an active state for inputting external waveform data and an inactive state where the external waveform data is not inputted. A detector device is provided to produces a detection signal when the input device switches between the active state and the inactive state.

Abstract: An accompaniment apparatus has a first memory for memorizing a plurality of original accompaniment patterns corresponding to various accompaniment styles, each original accompaniment pattern being composed of a set of parallel part patterns. An editor is operated for designating different ones of the original accompaniment patterns and collecting therefrom a set of desired part patterns to define a free accompaniment pattern which is different than the original accompaniment patterns. A second memory memorizes designated and collected results by the editor for use in reproduction of the free accompaniment pattern. During the reproduction, a pattern length difference or a meter difference among the set of the collected parallel part patterns can be corrected to maintain a consistent progression of the automatic free accompaniment.