Abstract: A pneumatic tire comprises: a tread portion having a ground contacting surface; a sidewall portions having an outer surface; a bead portions; a carcass extending between the bead portions; and an inner rubber extending between bead portions. The inner rubber comprises a first portion extending through the tread portion with a first thickness t1, and a second portion extending through the sidewall portion with a second thickness t2. The first thickness t1 is more than the second thickness t2. In a meridian cross section of the tire under its normal state, when a first reference point (Pb1), a second reference point (Pb2), a shoulder reference point (Ps), a reference line segment (Lb), and a shoulder line segment (Ls) are defined, then a length (L1) of the shoulder line segment (Ls) is 85.9% to 89.3% of a length (L2) of the reference line segment (Lb).

Abstract: A pneumatic tire comprises a tread portion, a pair of sidewall portions, a pair of bead portions, a carcass extending between the portions, and an inner rubber extending between the portions, on the inner side of the carcass. The inner rubber comprises a first portion extending through the tread portion with a first thickness and a second portion extending through the sidewall portions with a second thickness smaller than the first thickness. The land ratio of the tread portion 2 is 65% or more.

Abstract: Disclosed are constitutively active nuclear orphan receptors (CAR), which include one or more mutations which decrease the constitutive nature of CAR in vitro. The resulting non-constitutively active nuclear orphan receptors can be used to screen for agents that metabolize xenochemicals and/or steroids.

Abstract: Disclosed are constitutively active nuclear orphan receptors (CAR), which include one or more mutations which decrease the constitutive nature of CAR in vitro. The resulting non constitutively active nuclear orphan receptors can be used to screen for agents that metabolize xenochemicals and/or steroids.