Patents by Inventor Tatsuya Yamagishi
Tatsuya Yamagishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12110287Abstract: The present invention relates to heterocyclic derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: December 26, 2019Date of Patent: October 8, 2024Assignee: RaQualia Pharma Inc.Inventors: Tatsuya Yamagishi, Kiyoshi Kawamura, Yuji Shishido, Ryuichi Yamaguchi, Mikio Morita, Norikazu Gaja
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Patent number: 11802120Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.Type: GrantFiled: April 9, 2019Date of Patent: October 31, 2023Assignee: RaQualia Pharma Inc.Inventors: Masashi Ohmi, Takeshi Matsushita, Kazuo Ando, Ryuichi Yamaguchi, Yutaka Fukumoto, Ryohei Magara, Tatsuya Yamagishi, Mikito Takefuji
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Publication number: 20230339934Abstract: This invention relates to pyrimidin-4(3H)-one derivatives that act as modulators of the TRPV4 receptor. The present invention also relates to processes for the preparation of novel pyrimidin-4(3H)-one derivatives and to their use in the treatment of a wide range of diseases, syndromes, and disorders, in particular for the treatment of inflammatory, pain, and urological diseases or disorders.Type: ApplicationFiled: April 30, 2021Publication date: October 26, 2023Applicant: RaQualia Pharma Inc.Inventors: Yuji SHISHIDO, Tadashi INOUE, Tatsuya YAMAGISHI, Kazuo ANDO, Yutaka FUKUMOTO, Ryohei MAGARA
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Publication number: 20220048892Abstract: The present invention relates to heterocyclic derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: ApplicationFiled: December 26, 2019Publication date: February 17, 2022Applicant: RaQualia Pharma Inc.Inventors: Tatsuya YAMAGISHI, Kiyoshi KAWAMURA, Yuji SHISHIDO, Ryuichi YAMAGUCHI, Mikio MORITA, Norikazu GAJA
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Patent number: 11236790Abstract: A ventilated type brake disc rotor includes: a pair of sliding plates shaped annular and disposed opposite to each other in an axle direction; and joints formed to connect between the sliding plates and arranged along lines extending in a circumferential direction of the sliding plates. The joints include first joints arranged along a first line and second joints arranged along a second line located in an outer side with respect to the first line in a radial direction of the sliding plates. Each of the second joints includes a first width part and a second width part formed in an inner side with respect to the first width part in the radial direction. The second width part is less in circumferential width than the first width part, and is shaped to decrease in circumferential width as going inwardly in the radial direction.Type: GrantFiled: December 10, 2019Date of Patent: February 1, 2022Assignee: KIRIU CORPORATIONInventors: Toshikazu Okamura, Tatsuya Yamagishi, Tatsuya Saito
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Patent number: 11154544Abstract: The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: June 20, 2018Date of Patent: October 26, 2021Assignee: RaQualia Pharma Inc.Inventors: Tatsuya Yamagishi, Mikio Morita, Yuji Shishido, Ryuichi Yamaguchi, Norikazu Gaja
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Patent number: 11020381Abstract: The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: August 31, 2018Date of Patent: June 1, 2021Assignees: RaQualia Pharma Inc., XuanZhu Pharma Co., Ltd.Inventors: Kiyoshi Kawamura, Tatsuya Yamagishi, Yuji Shishido, Mikio Morita, Ryuichi Yamaguchi, Masashi Ohmi
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Publication number: 20210078975Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.Type: ApplicationFiled: April 9, 2019Publication date: March 18, 2021Applicants: RaQualia Pharma Inc., National University Corporation Tokai National Higher Education and Research SystemInventors: Masashi OHMI, Takeshi MATSUSHITA, Kazuo ANDO, Ryuichi YAMAGUCHI, Yutaka FUKUMOTO, Ryohei MAGARA, Tatsuya YAMAGISHI, Mikito TAKEFUJI
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Publication number: 20210062881Abstract: A ventilated type brake disc rotor includes: a pair of sliding plates shaped annular and disposed opposite to each other in an axle direction; and joints formed to connect between the sliding plates and arranged along lines extending in a circumferential direction of the sliding plates. The joints include first joints arranged along a first line and second joints arranged along a second line located in an outer side with respect to the first line in a radial direction of the sliding plates. Each of the second joints includes a first width part and a second width part formed in an inner side with respect to the first width part in the radial direction. The second width part is less in circumferential width than the first width part, and is shaped to decrease in circumferential width as going inwardly in the radial direction.Type: ApplicationFiled: December 10, 2019Publication date: March 4, 2021Applicant: KIRIU CORPORATIONInventors: Toshikazu OKAMURA, Tatsuya YAMAGISHI, Tatsuya SAITO
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Publication number: 20200230123Abstract: The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: ApplicationFiled: August 31, 2018Publication date: July 23, 2020Applicants: RaQualia Pharma Inc., XuanZhu Pharma Co., Ltd.Inventors: Kiyoshi KAWAMURA, Tatsuya YAMAGISHI, Yuji SHISHIDO, Mikio MORITA, Ryuichi YAMAGUCHI, Masashi OHMI
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Publication number: 20200016135Abstract: The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: ApplicationFiled: June 20, 2018Publication date: January 16, 2020Applicant: RaQualia Pharma Inc.Inventors: Tatsuya YAMAGISHI, Mikio MORITA, Yuji SHISHIDO, Ryuichi YAMAGUCHI, Norikazu GAJA
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Patent number: 9944634Abstract: The present invention relates to pyrazolopyridine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: October 31, 2013Date of Patent: April 17, 2018Assignee: RaQualia Pharma Inc.Inventors: Kiyoshi Kawamura, Tatsuya Yamagishi, Yoshimasa Arano, Mikio Morita
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Patent number: 9701658Abstract: The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: April 25, 2013Date of Patent: July 11, 2017Assignee: RaQualia Pharma Inc.Inventors: Tatsuya Yamagishi, Kiyoshi Kawamura, Mikio Morita
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Patent number: 9522140Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.Type: GrantFiled: July 2, 2015Date of Patent: December 20, 2016Assignee: RAQUALIA PHARMA INC.Inventors: Tadashi Inoue, Shuzo Watanabe, Tatsuya Yamagishi, Yoshimasa Arano, Mikio Morita, Kaoru Shimada
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Patent number: 9302991Abstract: The present invention relates to arylamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: October 18, 2011Date of Patent: April 5, 2016Assignee: RaQualia Pharma Inc.Inventors: Tatsuya Yamagishi, Kiyoshi Kawamura, Yoshimasa Arano, Mikio Morita
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Patent number: 9187475Abstract: The present invention relates to pyrrolopyridinone derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: GrantFiled: April 25, 2013Date of Patent: November 17, 2015Assignee: RaQualia Pharma Inc.Inventors: Kiyoshi Kawamura, Mikio Morita, Tatsuya Yamagishi
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Publication number: 20150322052Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.Type: ApplicationFiled: July 2, 2015Publication date: November 12, 2015Inventors: Tadashi INOUE, Shuzo WATANABE, Tatsuya YAMAGISHI, Yoshimasa ARANO, Mikio MORITA, Kaoru SHIMADA
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Publication number: 20150291582Abstract: The present invention relates to pyrazolopyridine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.Type: ApplicationFiled: October 31, 2013Publication date: October 15, 2015Applicant: RaQualia Pharma Inc.Inventors: Kiyoshi Kawamura, Tatsuya Yamagishi, Yoshimasa Arano, Mikio Morita
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Patent number: 9101616Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.Type: GrantFiled: May 31, 2010Date of Patent: August 11, 2015Assignee: RaQualia Pharma Inc.Inventors: Tadashi Inoue, Shuzo Watanabe, Tatsuya Yamagishi, Yoshimasa Arano, Mikio Morita, Kaoru Shimada
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Patent number: 9051296Abstract: The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar1 is phenyl; Ar2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO2—, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.Type: GrantFiled: November 16, 2010Date of Patent: June 9, 2015Assignee: RaQualia Pharma Inc.Inventors: Tatsuya Yamagishi, Yoshimasa Arano, Mikio Morita, Tadashi Inoue