Patents by Inventor Tatyana Budker

Tatyana Budker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid injected into hepatic vein lumen
    Patent number: 7547683
    Abstract: Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 16, 2009
    Assignee: Roche Madison, Inc.
    Inventors: Jon A. Wolff, Tatyana Budker, legal representative, Julia Hegge, James E. Hagstrom, Vladimir G. Budker
  • Reversible Hydrophobic Modification of Drugs for Improved Delivery to Cells
    Publication number: 20090074885
    Abstract: Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytically labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells are described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 19, 2009
    Applicant: Roche Madison Inc.
    Inventors: Sean D. Monahan, Vladimir Subbotin, Zane C. Neal, Vladimir G. Budker, Tatyana Budker
  • Chelating Compound for Drug Delivery
    Publication number: 20070219363
    Abstract: Chelator containing compounds are utilized in the delivery of molecules and polymers to animal cells. At least one chelator such as crown ether is attached to a polymer and then associated with another polymer. An ion is then added to the mixture thereby forming condensed polymer. In condensed form and in complex with the chelator, polymer can be delivered to a cell.
    Type: Application
    Filed: April 20, 2007
    Publication date: September 20, 2007
    Inventors: Vladimir Budker, Jon Wolff, Sean Monahan, Paul Slattum, James Hagstrom, Vladimir Trubetskoy, Tatyana Budker
  • Endosomolytic Polymers
    Publication number: 20070036865
    Abstract: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
    Type: Application
    Filed: September 19, 2006
    Publication date: February 15, 2007
    Applicant: MIRUS BIO CORPORATION
    Inventors: David Rozema, Darren Wakefield, Jon Wolff, Vladimir Budker, Tatyana Budker, Sean Monahan, Vladimir Trubetskoy, James Hagstrom, Aaton Loomis, Paul Slattum
  • Micellar systems
    Publication number: 20070010004
    Abstract: Methods are described for modifying nucleic acids to facilitate delivery of the nucleic acids to cells. Compounds which interact with of modify nucleic acids are interacted with the nucleic acids within reverse micelles.
    Type: Application
    Filed: June 30, 2006
    Publication date: January 11, 2007
    Inventors: Sean Monahan, Vladimir Budker, Tatyana Budker, Jon Wolff, Paul Slattum, James Hagstrom