Patents by Inventor Tatyana D. Sotnikova

Tatyana D. Sotnikova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treatment using arylcyclopropylamine compounds
    Patent number: 9585850
    Abstract: The present invention is directed to a method of treating Parkinson's disease using arylcyclopropylamine compounds. The arylcyclopropylamine compounds have the following formula wherein R1, R2, R3, R4, R5 and R6 are described herein.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: March 7, 2017
    Assignee: Duke University
    Inventors: Dewey G. McCafferty, Julie A. Pollock, David M. Gooden, Marc G. Caron, Raul R. Gainetdinov, Tatyana D. Sotnikova
  • METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
    Publication number: 20150258044
    Abstract: Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.
    Type: Application
    Filed: October 14, 2014
    Publication date: September 17, 2015
    Inventors: Dewey G. McCafferty, Julie A. Pollock, David M. Gooden, Marc G. Caron, Raul R. Gainetdinov, Tatyana D. Sotnikova
  • Antiparkinsonian Action of Phenylisopropylamines
    Publication number: 20150025063
    Abstract: A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: Marc G. Caron, Tatyana D. Sotnikova, Raul R. Gainetdinov
  • Antiparkinsonian action of phenylisopropylamines
    Patent number: 8877802
    Abstract: A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: November 4, 2014
    Assignee: Duke Univerity
    Inventors: Marc G. Caron, Tatyana D. Sotnikova, Raul R. Gainetdinov
  • Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    Patent number: 8124831
    Abstract: Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: February 28, 2012
    Assignee: Duke University
    Inventors: Marc G. Caron, Xiaodong Zhang, Martin Beaulieu, Raul R. Gainetdinov, Tatyana D. Sotnikova