Abstract: In one example, a server system interfaces with a plurality of remotely-situated client entities to provide data communications services. The system uses processing circuitry to access an archive of voice data indicative of transcribed audio conversations between a client station and another station participating via the data communications services. Archived voice data includes keywords associated with at least one intent or at least one topic of the transcribed audio conversations. The system identifies keywords and/or identified contexts in a message (e.g., text-based message) received by a text-based virtual assistant, and correlates the text-based message with at least one intent or at least one topic by matching keywords from the archive of digital voice data with the identified keywords from the text-based message. The system may automatically configure the virtual assistant associated with the remotely-situated client entity to address the received text-based message, based on the correlation.

Abstract: Exemplary aspects involve a data-communications apparatus or system communicate over a broadband network with a plurality of remotely-located data-communications circuits respectively associated with a plurality of remotely-situated client entities. The system includes data-communications platform (e.g., UC-CC) that processes incoming data-communication interactions including different types of digitally-represented communications among which are incoming call, and that is integrated with a memory circuit including a database of information sets. Each of the information sets includes experience data corresponding to past incoming data-communication interactions processed by the platform, and with aggregated and organized data based on data collected in previous incoming interactions.

Abstract: The disclosure provides gene therapy vectors, such as adeno-associated virus (AAV), designed for treatment of Lysosomal Acid Lipase Deficiency (LAL-D) disorders such as Wolman Disease and cholesterol ester storage disease (CESD). The disclosed rAAV provide a wild type lipase A (LIRA) cDNA to a subject in need which results in expression of the wild type protein.

Abstract: This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

Abstract: This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: The disclosure provides gene therapy vectors, such as adeno-associated virus (AAV), optimized for delivering a transgene to muscles. The optimized vectors contain constitutive or a muscle-specific promoter to deliver whole body or skeletal/heart muscle-specific transgene expression, respectively, in combination with a transgene cDNA to replace the gene mutation found in a muscle disease with a normal copy of the gene, an internal ribosomal entry site (IRES) to allow for production of a second protein from the same transcript, and a muscle growth factor, to build new muscle growth and strength. For example, the invention provides The disclosure provides gene therapy vectors, such as recombinant adeno-associated vims (rAAV), designed for treatment of GNE myopathy in which the rAAV expresses UDP-GlcNAc-epimerase/ManNAc-6 alone or in combination with a muscle growth factor or muscle transdifferentation factor.

Abstract: A radiation detector (100) includes a photovoltaic layer (102) with first and second opposing sides. The photovoltaic layer is configured to absorb first radiation at the first side and produce electrical charge. The detector further includes a porous silicon quantum dot layer (104) disposed at the second side of the photovoltaic layer and configured to receive second radiation and convert the received second radiation into an electrical signal indicative of an energy level of the received second radiation. The detector further includes an acquisition and communication layer (106) disposed adjacent to the porous silicon quantum dot layer and configured to receive the electrical signal and transmit the electrical signal to a device remote from the radiation detector.

Abstract: An aircraft-based runway overrun awareness alerting system (ROAAS) for an aircraft primary flight display (PFD) is disclosed. In embodiments, the ROAAS is embodied aboard an aircraft and tracks trends in the aircraft position and heading. Further, the ROAAS tracks the trending energy state of the aircraft on approach to a runway. Based on the current energy state, as well as the runway parameters, the ROAAS predicts a landing point for the aircraft along the runway as a trend based on the evolving energy state and position of the aircraft. Based on the landing point trend, as well as the energy state, the ROAAS determines the current likelihood of runway excursion as an evolving trend (e.g., that the aircraft will not have sufficient runway remaining to decelerate or stop) and displays this likelihood as a dynamic graphic element not integrated into any other instruments or components displayed by the PFD.

Abstract: An aircraft-based runway overrun awareness alerting system (ROAAS) for an aircraft primary flight display (PFD) is disclosed. In embodiments, the ROAAS is embodied aboard an aircraft and tracks the position and heading of the aircraft. Further, the ROAAS tracks the energy state of the aircraft as it approaches a runway for landing. Based on the current energy state, as well as the runway parameters, the ROAAS predicts a landing point for the aircraft along the runway. Based on this landing point, as well as the current energy state, the ROAAS determines the current likelihood of runway excursion (e.g., that the aircraft will not have sufficient runway remaining to decelerate or stop) and displays this likelihood as a dynamic graphic element not integrated into any other instruments or components displayed by the PFD.

Abstract: An aircraft-based runway overrun awareness alerting system (ROAAS) for an aircraft primary flight display (PFD) is disclosed. In embodiments, the ROAAS is embodied aboard an aircraft and tracks trends in the aircraft position and heading. Further, the ROAAS tracks the trending energy state of the aircraft on approach to a runway. Based on the current energy state, as well as the runway parameters, the ROAAS predicts a landing point for the aircraft along the runway as a trend based on the evolving energy state and position of the aircraft. Based on the landing point trend, as well as the energy state, the ROAAS determines the current likelihood of runway excursion as an evolving trend (e.g., that the aircraft will not have sufficient runway remaining to decelerate or stop) and displays this likelihood as a dynamic graphic element not integrated into any other instruments or components displayed by the PFD.

Abstract: An aircraft-based runway overrun awareness alerting system (ROAAS) for an aircraft primary flight display (PFD) is disclosed. In embodiments, the ROAAS is embodied aboard an aircraft and tracks the position and heading of the aircraft. Further, the ROAAS tracks the energy state of the aircraft as it approaches a runway for landing. Based on the current energy state, as well as the runway parameters, the ROAAS predicts a landing point for the aircraft along the runway. Based on this landing point, as well as the current energy state, the ROAAS determines the current likelihood of runway excursion (e.g., that the aircraft will not have sufficient runway remaining to decelerate or stop) and displays this likelihood as a dynamic graphic element not integrated into any other instruments or components displayed by the PFD.

Abstract: The present disclosure relates to recombinant adeno-associated virus (rAAV) delivery of a GALGT2 polynucleotide. The disclosure provides rAAV and methods of using the rAAV for GALGT2 gene therapy of neuromuscular disorders. Exemplary neuromuscular disorders include, but are not limited to, muscular dystrophies such as Duchenne muscular dystrophy, Congenital Muscular Dystrophy 1A and Limb Girdle Muscular Dystrophy 2D.

Abstract: A radiation detector (100) includes a photovoltaic layer (102) with first and second opposing sides. The photovoltaic layer is configured to absorb first radiation at the first side and produce electrical charge. The detector further includes a porous silicon quantum dot layer (104) disposed at the second side of the photovoltaic layer and configured to receive second radiation and convert the received second radiation into an electrical signal indicative of an energy level of the received second radiation. The detector further includes an acquisition and communication layer (106) disposed adjacent to the porous silicon quantum dot layer and configured to receive the electrical signal and transmit the electrical signal to a device remote from the radiation detector.

Abstract: The present disclosure relates to recombinant adeno-associated virus (rAAV) delivery of a GALGT2 polynucleotide. The disclosure provides rAAV and methods of using the rAAV for GALGT2 gene therapy of neuromuscular disorders. Exemplary neuromuscular disorders include, but are not limited to, muscular dystrophies such as Duchenne muscular dystrophy, Congenital Muscular Dystrophy 1A and Limb Girdle Muscular Dystrophy 2D.

Abstract: The present disclosure relates to recombinant adeno-associated virus (rAAV) delivery of a GALGT2 polynucleotide. The disclosure provides rAAV and methods of using the rAAV for GALGT2 gene therapy of neuromuscular disorders. Exemplary neuromuscular disorders include, but are not limited to, muscular dystrophies such as Duchenne muscular dystrophy, Congenital Muscular Dystrophy 1A and Limb Girdle Muscular Dystrophy 2D.

Abstract: Phage peptide display technology was used to identify peptides that bind specifically to the amyloid form of the A?1-40 peptide. Peptides with similar structural features and bind to the amyloid form of A?1-40 but not to monomeric A?1-40, are provided. Such peptides are useful as carrier molecules to deliver therapeutic and diagnostic reagents to amyloid plaques.