Patents by Inventor Tayyaba Hasan

Tayyaba Hasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220142922
    Abstract: Provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a strained cyclooctyne moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. Also provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a targeting moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. The liposomes provided herein can be used, for example, in the treatment of cancer or in the imaging of cancer tumors.
    Type: Application
    Filed: August 3, 2021
    Publication date: May 12, 2022
    Inventors: Girgis Obaid, Tayyaba Hasan
  • Publication number: 20220016436
    Abstract: A low-cost light delivery system includes a light source device and a light delivery applicator. The light source device includes a light source (e.g., a light emitting diode, a laser, or the like) mounted on a passive heat sink and coupled to an optical fiber extending out of the light source device to carry a light signal. The light source device also includes a microcontroller configured to define a required irradiance to be delivered by the light signal based on a prescribed dosimetry parameter; and one or more power sources, each configured to provide power to at least one of the high powered light emitting diode and the microcontroller. The light delivery applicator can be removably connected to the optical fiber and configured to be placed proximal to an area of the patient to deliver the required irradiance of the light signal to the area of the patient.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 20, 2022
    Inventors: Tayyaba Hasan, Jonathan P. Celli, Imran Rizvi, Filip Cuckov, Hui Liu
  • Patent number: 10874107
    Abstract: Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 29, 2020
    Assignees: The General Hospital Corporation, New England Biolabs
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Barton Slatko, Jeremy Foster
  • Publication number: 20200154710
    Abstract: Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 21, 2020
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Barton Slatko, Jeremy Foster
  • Publication number: 20200041413
    Abstract: The present disclosure features portable wide field fluorimeter systems, e.g., in the form of low-cost mobile platforms, and methods to perform fluorometric assays to detect a change in fluorescence intensity in liquid samples, e.g., caused by the presence of a target analyte, e.g., a protein, e.g., an enzyme (e.g., ?-lactamase) expressed by a target pathogen in a liquid sample in a point-of-care setting. In some implementations, a portable system for detecting a change in fluorescence intensity in a liquid sample includes a microfluidic device, an optical assembly including an emission filter and one or more lenses, and an analyzer device that collects and processes a fluorescent signal for the detection of a target analyte produced by the target pathogen present in the liquid sample.
    Type: Application
    Filed: January 19, 2018
    Publication date: February 6, 2020
    Inventors: Akilan Palanisami, Tayyaba Hasan
  • Patent number: 10465226
    Abstract: One aspect of the present disclosure relates to a device for detecting a target analyte in a liquid sample. The device can comprise a housing. The housing can include an inlet for receiving a liquid sample, an outlet for removing a volume of the liquid sample from the device, a filter associated with the outlet and being sized and dimensioned to retain a target analyte on a surface thereof, and a flow system comprising at least one channel that is in communication with the inlet and the outlet. At least a portion of the at least one channel can be located substantially adjacent the surface of the filter and be shaped and dimensioned to reduce the amount of unreacted fluorescent probe available to create the background interference during detection of the target analyte.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 5, 2019
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Tayyaba Hasan, Akilan Palanisami, Shazia Khan
  • Patent number: 10426388
    Abstract: A method for measuring differential blood oxygen saturation in a solid tumor is described that includes the steps of obtaining a first oxygenation image of a solid tumor before, during, or immediately after a administration of vascular therapy; obtaining a second oxygenation image of the solid tumor after a devascularization time period; and determining a differential blood oxygen saturation value by comparing the first oxygenation image and the second oxygenation image. The differential blood oxygen saturation value can be compared to a blood oxygen saturation necrosis value to provide a prognosis for tumor recurrence, or to guide of the tumor.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: October 1, 2019
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Tayyaba Hasan, Srivalleesha Mallidi
  • Publication number: 20180161272
    Abstract: Provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a strained cyclooctyne moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. Also provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a targeting moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. The liposomes provided herein can be used, for example, in the treatment of cancer or in the imaging of cancer tumors.
    Type: Application
    Filed: May 26, 2016
    Publication date: June 14, 2018
    Inventors: Girgis Obaid, Tayyaba Hasan
  • Publication number: 20180094292
    Abstract: The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 5, 2018
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Sarika Verma, Gerard Nau
  • Patent number: 9828622
    Abstract: The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: November 28, 2017
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Sarika Verma, Gerard Nau
  • Publication number: 20170233785
    Abstract: One aspect of the present disclosure relates to a device for detecting a target analyte in a liquid sample. The device can comprise a housing. The housing can include an inlet for receiving a liquid sample, an outlet for removing a volume of the liquid sample from the device, a filter associated with the outlet and being sized and dimensioned to retain a target analyte on a surface thereof, and a flow system comprising at least one channel that is in communication with the inlet and the outlet. At least a portion of the at least one channel can be located substantially adjacent the surface of the filter and be shaped and dimensioned to reduce the amount of unreacted fluorescent probe available to create the background interference during detection of the target analyte.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 17, 2017
    Inventors: Tayyaba Hasan, Akilan Palanisami, Shazia Khan
  • Publication number: 20170135615
    Abstract: A method for measuring differential blood oxygen saturation in a solid tumor is described that includes the steps of obtaining a first oxygenation image of a solid tumor before, during, or immediately after a administration of vascular therapy; obtaining a second oxygenation image of the solid tumor after a devascularization time period; and determining a differential blood oxygen saturation value by comparing the first oxygenation image and the second oxygenation image. The differential blood oxygen saturation value can be compared to a blood oxygen saturation necrosis value to provide a prognosis for tumor recurrence, or to guide of the tumor.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 18, 2017
    Inventors: Tayyaba Hasan, Srivalleesha Mallidi
  • Publication number: 20160345834
    Abstract: Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.
    Type: Application
    Filed: February 2, 2015
    Publication date: December 1, 2016
    Inventors: Tayyaba Hasan, Bryan Q. Spring, Akilan Palanasami
  • Publication number: 20160073634
    Abstract: Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.
    Type: Application
    Filed: June 21, 2013
    Publication date: March 17, 2016
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Barton Slatko, Jeremy Foster
  • Publication number: 20110112059
    Abstract: The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.
    Type: Application
    Filed: May 5, 2009
    Publication date: May 12, 2011
    Applicant: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Ulysses W. Sallum, Sarika Verma
  • Publication number: 20100016208
    Abstract: Photoactivatable antimicrobial compounds and methods for the use thereof in the treatment of infections are provided.
    Type: Application
    Filed: November 15, 2006
    Publication date: January 21, 2010
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Tayyaba Hasan, Gerald J. Nau
  • Publication number: 20090304803
    Abstract: The invention generally provides methods and compositions useful for providing photodynamic therapy to specific cells or tissues.
    Type: Application
    Filed: June 6, 2006
    Publication date: December 10, 2009
    Applicant: The General Hospital Corporation
    Inventor: Tayyaba Hasan
  • Patent number: 7498029
    Abstract: The present invention relates to photosensitizer immunoconjugate compositions and combination therapies for use in cancer related photodynamic treatments and diagnostic methods. Photosensitizer immunoconjugates comprising a photosensitizer conjugated to a tumor-specific and/or tumoricidial antibody and processes for the preparation thereof are described. The use of photosensitizer immunoconjugates (PICs) offers improved photosensitizer delivery specificity for diagnostic and therapeutic applications. Combination therapies to co-localize activated photosensitizer compounds and tumoricidal antibodies in tumor tissues are also described.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: March 3, 2009
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Mark D. Savellano, Mihaela Skobe
  • Publication number: 20080312150
    Abstract: A method of treating a subject having unwanted cell proliferation which includes: inducing differentiation in a cell; providing said cell with a photosensitizer; and activating said PS, thereby the treating unwanted cell proliferation.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 18, 2008
    Applicant: Massachusetts General Hospital, Partners HealthCare Research Ventures & Licensing
    Inventors: Tayyaba Hasan, Bernard Ortel
  • Publication number: 20080206804
    Abstract: Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the sample and second data associated with second luminescent characteristics of at least one second molecule of the sample can be obtained based on the unpartitioned electro-magnetic radiation. At least two of the photo-luminescent properties of the sample may be measured simultaneously as a function of the first and second data. Further, the information regarding the molecules of the sample may be determined as a function of the photo-luminescent properties.
    Type: Application
    Filed: January 17, 2008
    Publication date: August 28, 2008
    Applicant: The General Hospital Corporation
    Inventors: Guillermo J. Tearney, Brett E. Bouma, Leilei Peng, Tayyaba Hasan, Sarika Verma