Patents by Inventor Te Piao King

Te Piao King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7060265
    Abstract: A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent “intronic” sequences. In still a further enbodiment, genetic engineering permits the construction of the “intronic” sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: June 13, 2006
    Assignee: The Rockefeller University
    Inventor: Te Piao King
  • Publication number: 20040175393
    Abstract: A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent “intronic” sequences. In still a further enbodiment, genetic engineering permits the construction of the “intronic” sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.
    Type: Application
    Filed: October 17, 2003
    Publication date: September 9, 2004
    Applicant: The Rockefeller University
    Inventor: Te Piao King
  • Patent number: 6652851
    Abstract: A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent “intronic” sequences. In still a further embodiment, genetic engineering permits the construction of the “intronic” sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: November 25, 2003
    Assignee: The Rockefeller University
    Inventor: Te Piao King
  • Publication number: 20030039660
    Abstract: Disclosed are recombinant hybrid proteins having at least one antigenic peptide sequence introduced into a scaffold protein that retain a native conformation. Also disclosed are recombinant nucleic acids and vectors encoding the hybrid proteins. The hybrid proteins retain immunogenicity but exhibit reduced allergenicity. The hybrid proteins are therefore particularly useful for therapeutic treatment of allergy.
    Type: Application
    Filed: March 4, 2002
    Publication date: February 27, 2003
    Applicant: The Rockefeller University
    Inventors: Te Piao King, Michael Dho Spangfort
  • Patent number: 6372471
    Abstract: The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom enzymes, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase, for example, Polistes annularis phospholipase A1, and vespid venom hyaluronidase, for example, Polistes annularis hyaluronidase.
    Type: Grant
    Filed: October 1, 1998
    Date of Patent: April 16, 2002
    Assignee: The Rockefeller University
    Inventor: Te Piao King
  • Patent number: 6287559
    Abstract: The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom enzymes, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase, for example, Dolichovespula maculata phospholipase and Vespula vulgaris phospholipase, and vespid venom hyaluronidase, for example, Dolichovespula maculata hyaluronidase.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 11, 2001
    Assignee: The Rockefeller University
    Inventor: Te Piao King
  • Patent number: 6270763
    Abstract: The present invention is directed to nucleic acids encoding vespid venom phospholipases, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom phospholipases, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase A1, for example, Dolichovespula maculata phospholipase A1 and Vespula vulgaris phospholipase A1.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 7, 2001
    Inventor: Te Piao King
  • Patent number: 6106844
    Abstract: The present invention is directed to immunogenic peptides from vespid antigen 5. These immunogenic peptides can be used in immunotherapy for vespid venom allergic individuals. The present invention is thus directed to T cell epitopes of vespid antigen 5 that can anergize T cell responses in sensitive individuals.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: August 22, 2000
    Assignee: The Rockfeller University
    Inventor: Te Piao King
  • Patent number: 5804201
    Abstract: The present invention is directed to immunogenic peptides from vespid antigen 5. These immunogenic peptides can be used in immunotherapy for vespid venom allergic individuals. The present invention is thus directed to T cell epitopes of vespid antigen 5 that can anergize T cell responses in sensitive individuals.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: September 8, 1998
    Assignee: The Rockefeller University
    Inventor: Te Piao King