Abstract: Disclosed are systems and methods for network configuration management systems and methods. In some embodiments, the discloses systems and methods may involve receiving data from one or more nodes within a particular network. The data may include, for example, topology, telemetry, geographical, and other data relating to the nodes, the network, and/or the functionality of the nodes or network. Once received, such data may be cleaned and processing may be performed on the data. Such processing may involve clustering the data into groups based on various parameters and performing forecasting on the data to determine future usage rates and capacity information, for example. The clustering and forecasting results may be fed to a rules engine and/or an optimization engine, which may then determine appropriate actions to take on the network (e.g., changes to various nodes in terms of technology and/or number of nodes).

Abstract: Example systems, devices, media, and methods are described for tracking one or more movable objects and presenting virtual elements on a display in proximity to the tracked movable objects. One or more ultra-wideband (UWB) transmitters are mounted to each movable object in a physical environment including at least two synchronized UWB receivers. The receivers calculate a current location of each movable object. A plurality of portable electronic devices, including one or more eyewear devices, are paired with the receivers in a network. A localization application determines a current location of each eyewear device. A rendering application presents one or more virtual elements on a display as an overlay relative to the current movable object location and in relative proximity to the current eyewear location. The physical environment is represented by a static mesh. A time synchronized tracking application identifies moving items that are not coupled to a UWB transmitter.

Abstract: Example systems, devices, media, and methods for tracking movable objects and presenting virtual elements on a display in proximity to the movable objects. Ultra-wideband (UWB) transmitters are mounted to each movable object in an environment including at least two synchronized UWB receivers. The receivers calculate current locations of movable objects. Portable electronic devices, including eyewear devices, are paired with the receivers in a network. A localization application determines a current location of each eyewear device. A rendering application presents virtual elements on a display as an overlay relative to the current movable object location and in relative proximity to the current eyewear location. The physical environment is represented by a static mesh. A time synchronized tracking application identifies moving items that are not coupled to a UWB transmitter. The rendering application presents the virtual elements on the display in accordance with the static mesh and the moving items.

Abstract: Sampling of food products and/or surfaces can be efficiently carried out by providing an apparatus comprising a bag construction incorporating a sample collection material secured to an inside surface of the bag. The bag is of a size large enough to permit inversion of the bag to expose the sample collection material for collection of samples from surfaces, followed by re-inversion to enclose the sample collection material. Methods for sampling food products and/or surfaces for detection of pathogens, microbial contaminants and/or constituents in products or on surfaces are additionally contemplated.

Abstract: Example systems, devices, media, and methods are described for tracking one or more movable objects and presenting virtual elements on a display in proximity to the tracked movable objects. One or more ultra-wideband (UWB) transmitters are mounted to each movable object in a physical environment including at least two synchronized UWB receivers. The receivers calculate a current location of each movable object. A plurality of portable electronic devices, including one or more eyewear devices, are paired with the receivers in a network. A localization application determines a current location of each eyewear device. A rendering application presents one or more virtual elements on a display as an overlay relative to the current movable object location and in relative proximity to the current eyewear location. The physical environment is represented by a static mesh. A time synchronized tracking application identifies moving items that are not coupled to a UWB transmitter.

Abstract: Sampling of food products and/or surfaces can be efficiently carried out by providing an apparatus comprising a bag construction incorporating a sample collection material secured to an inside surface of the bag. The bag is of a size large enough to permit inversion of the bag to expose the sample collection material for collection of samples from surfaces, followed by re-inversion to enclose the sample collection material. Methods for sampling food products and/or surfaces for detection of pathogens, microbial contaminants and/or constituents in products or on surfaces are additionally contemplated.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: The present invention includes a method for preparing a meat product that includes subjecting meat material to ultrasonic energy to reduce the microbial content of the meat material. One embodiment of the method includes subjecting the meat material to ultrasonic energy further comprises subjecting the meat material to about 1×10?4 to about 1 kilowatt-hour ultrasonic energy per liter meat material. In other embodiments the application of the ultrasonic energy can be varied in terms of energy, duration time, frequency, and temperature to achieve the desired results.

Abstract: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described.

Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.

Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.