Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: A method and apparatus are provided for improving the functionality of a remote input device while allowing for the input device to perform a number of roles. This is achieved by providing a detachable keyboard within a portable computer capable of functioning as both a hardwired, internal input device and as a remote, wireless input device. The input device of the invention is capable of being housed within a portable computer and performs as a typical on-board input device. In addition, the input device may be removed from the base of the computer and used as an internally-powered wireless control device. In the latter mode the communication between the input device and the computer takes place through a wireless link existing between the input device and the computer.

Abstract: A communication device capable of selectively communicating control signals to a computer and transmitting a narrow beam of light. A cordless communication device is provided having operational buttons and a port. The communication device may function as a computer mouse, a trackball apparatus, or a touch pad apparatus. Operational signals are generated by a signal generator in response to activation of the operational buttons or movement of a mouse ball. The communication device further includes a light generating apparatus in communication with the port which generates the narrow beam of light. A selectively operable switch is provided for selectively transmitting the operational signals or the beam of light. The communication device includes an independent power supply as well as a power level monitor and switching apparatus. Preferably, the beam of light is a laser beam or other focused beam of light.

Abstract: An apparatus simultaneously displays the output of two or more computers on a single monitor in a manner similar to the manner in which television sets provide picture-in-picture (PIP) viewing. In one embodiment, computer video is converted to a format such as NTSC so that existing television set PIP circuits may be employed with little or no modification. In another embodiment, the PIP circuit accepts computer video inputs. In yet another embodiment, the apparatus utilizes a processor to control the content of the main display area and PIP window using cursor position. The apparatus also supplies input device signals, such as mouse and keyboard signals, to the computer corresponding to the main screen area and transmits dummy keyboard and mouse signals to other computers attached to the system.