Patents by Inventor Ted Laurence
Ted Laurence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11740454Abstract: In one inventive concept, a method for etching an optic includes obtaining a microemulsion, where the microemulsion includes a continuous oil phase, a surfactant system comprising at least one surfactant, and water, submerging at least a portion of the optic in the microemulsion, and agitating by ultrasonication the microemulsion for etching the optic submerged therein.Type: GrantFiled: March 26, 2018Date of Patent: August 29, 2023Assignee: Lawrence Livermore National Security, LLCInventors: Salmaan H. Baxamusa, John Adams, Paul Ehrmann, Ted Laurence, Marlon G. Menor, Kathleen I. Schaffers
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Patent number: 11598946Abstract: Devices, systems and methods for widefield three-dimensional (3D) microscopy with a quantum entanglement light source are described. An example method includes generating a first set of photons and a second set of photons, wherein each of the photons in the first set is quantum entangled with a corresponding photon in the second set, directing the second set of photons toward a sample and simultaneously directing the first set of photons toward a first two-dimensional (2D) detector, detecting, from the sample, a plurality of photons at a second 2D detector, analyzing detections from the first and second 2D detectors to determine coincidence information, and determining one or more characteristics associated with at least a three-dimensional (3D) section of the sample based on collective detections at the first and the second 2D detectors.Type: GrantFiled: October 14, 2020Date of Patent: March 7, 2023Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Tiziana C. Bond, Matthew A. Horsley, Shervin Kiannejad, Ted Laurence, Ty Samo, Peter Weber, Xiyu Yi
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Publication number: 20220113529Abstract: Devices, systems and methods for widefield three-dimensional (3D) microscopy with a quantum entanglement light source are described. An example method includes generating a first set of photons and a second set of photons, wherein each of the photons in the first set is quantum entangled with a corresponding photon in the second set, directing the second set of photons toward a sample and simultaneously directing the first set of photons toward a first two-dimensional (2D) detector, detecting, from the sample, a plurality of photons at a second 2D detector, analyzing detections from the first and second 2D detectors to determine coincidence information, and determining one or more characteristics associated with at least a three-dimensional (3D) section of the sample based on collective detections at the first and the second 2D detectors.Type: ApplicationFiled: October 14, 2020Publication date: April 14, 2022Inventors: Tiziana C. Bond, Matthew A. Horsley, Shervin Kiannejad, Ted Laurence, Ty Samo, Peter Weber, Xiyu Yi
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Publication number: 20210003841Abstract: In one inventive concept, a method for etching an optic includes obtaining a microemulsion, where the microemulsion includes a continuous oil phase, a surfactant system comprising at least one surfactant, and water, submerging at least a portion of the optic in the microemulsion, and agitating by ultrasonication the microemulsion for etching the optic submerged therein.Type: ApplicationFiled: March 26, 2018Publication date: January 7, 2021Inventors: Salmaan H. Baxamusa, John Adams, Paul Ehrmann, Ted Laurence, Marlon G. Menor, Kathleen I. Schaffers
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Patent number: 7599059Abstract: A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of each of the photons is determined. The interval of time between various photon pairs is then determined to provide photon pair intervals. The number of photons that have arrival times within the photon pair intervals is also determined. The photon pair intervals are then used in combination with the corresponding counts of intervening photons to analyze properties and interactions of the molecules including brightness, concentration, coincidence and transit time. The method can be used for analyzing single photon streams and multiple photon streams.Type: GrantFiled: July 25, 2003Date of Patent: October 6, 2009Assignee: The Regents of the University of CaliforniaInventors: Ted A. Laurence, Shimon Weiss
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Patent number: 7456954Abstract: Fluorescence, spectroscopy is used to analyze small numbers of molecules that are present in a relatively small detection volume or zone. Information regarding physical and chemical properties of these molecules is determined by rapidly modulating the wavelength, intensity and/or polarization of laser energy to excite fluorophores that are attached either to the molecule of interest or a molecule that interacts with the molecule of interest. The emission profile of the fluorophores is used to determine useful information about the labeled and/or non-labeled molecules including molecular interactions between the molecules.Type: GrantFiled: June 17, 2004Date of Patent: November 25, 2008Assignee: The Regents of the University of CaliforniaInventors: Shimon Weiss, Achillefs Kapanidis, Ted A. Laurence, Nam K. Lee
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Patent number: 7301624Abstract: Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.Type: GrantFiled: September 7, 2004Date of Patent: November 27, 2007Assignee: Lawrence Livermore National Security, LLCInventors: Chad E. Talley, Thomas R. Huser, Christopher W. Hollars, Stephen M. Lane, Joe H. Satcher, Jr., Bradley R. Hart, Ted A. Laurence
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Publication number: 20070109536Abstract: Fluorescence, spectroscopy is used to analyze small numbers of molecules that are present in a relatively small detection volume or zone. Information regarding physical and chemical properties of these molecules is determined by rapidly modulating the wavelength, intensity and/or polarization of laser energy to excite fluorophores that are attached either to the molecule of interest or a molecule that interacts with the molecule of interest. The emission profile of the fluorophores is used to determine useful information about the labeled and/or non-labeled molecules including molecular interactions between th molecules.Type: ApplicationFiled: June 17, 2004Publication date: May 17, 2007Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Shimon Weiss, Achillefs Kapanidis, Ted Laurence, Nam Lee
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Publication number: 20060176479Abstract: A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of each of the photons is determined. The interval of time between various photon pairs is then determined to provide photon pair intervals. The number of photons that have arrival times within the photon pair intervals is also determined. The photon pair intervals are then used in combination with the corresponding counts of intervening photons to analyze properties and interactions of the molecules including brightness, concentration, coincidence and transit time. The method can be used for analyzing single photon streams and multiple photon streams.Type: ApplicationFiled: July 25, 2003Publication date: August 10, 2006Applicant: The regents of the University of CaliforinaInventors: Ted Laurence, Shimon Weiss
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Publication number: 20060050268Abstract: Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.Type: ApplicationFiled: September 7, 2004Publication date: March 9, 2006Inventors: Chad Talley, Thomas Huser, Christopher Hollars, Stephen Lane, Joe Satcher, Bradley Hart, Ted Laurence