Abstract: Provided herein are methods of measuring immune health in a subject. In some embodiments, methods herein comprise, obtaining an immunological measurement from a biological sample from the subject, wherein the immunological measurement comprises antibody-peptide binding. Also provided are computer-implemented methods of predicting immune health, including computer-implemented machine learning algorithms useful in such predictions.

Abstract: The present invention provides methods for identifying monobactams with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of monobactams with anti-PBP2a activity from component reactants. The invention also provides novel monobactams with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of monobactams from component reactants.

Abstract: Methods are disclosed for producing chimeric nucleic acid molecules with two or more functionalities. A chimeric library is generated in which individual chimeric molecules combine the functions or characteristics of two or more parent libraries, each parent library having been selected through the SELEX procedure for a specific function or feature. The chimeric molecules of this invention are useful in a variety of ways, including having improved affinities for a target molecule, enhancing assembly of multi-component molecules, and promoting reactions between two molecules.

Abstract: Methods are disclosed for producing chimeric nucleic acid molecules with two or more functions. A chimeric library is generated in which individual chimeric molecules combine the functions or characteristics of two or more parent libraries, each parent library having been selected through the SELEX procedure for a specific function or feature. The chimeric molecules of this invention are useful in a variety of ways, including having improved affinities for a target molecule, enhancing assembly of multi-component molecules, and promoting reactions between two molecules.