Patents by Inventor Teemu Korpimäki
Teemu Korpimäki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220244249Abstract: A microplate comprising: a plurality of wells arranged in a two-dimensional array, each of the wells comprising: a bottom surface, sidewalls extending from the bottom surface to form an open top; and at least two subwells in the bottom surface, the at least two subwells having sidewalls that extend below the bottom surface of the well, wherein each of the at least two subwells comprises a capture binding agent that is configured to bind to a target analyte, if present, in a sample. A sample is added to the well such that the sample fluidically contacts each of the at least two subwells such that a target analyte, if present, binds to the capture binding agent in one or more of the at least two subwells, wherein a labeled conjugate (e.g., an upconverting nanoparticle (UCNP) labeled conjugate) in the sample binds with the target analyte, if present. A label (e.g.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Inventors: Teemu KORPIMÄKI, Mikko SAIRANEN, Ville VEIKKOLAINEN
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Publication number: 20220244277Abstract: A lateral flow test strip reader for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing having a lateral flow test strip receptacle for receiving a lateral flow test strip therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source that generates an excitation light beam; at least one lens for optically expanding the excitation light beam in a direction across the test region and the control region such that the excitation light beam is configured to simultaneously impinge and excite both the test region and the control region; and an optical detector configured to simultaneously detect an image comprising emission signals from the test region and the control region, wherein the detected emission signals indicate a presence or absence of a target in the sample.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Inventors: Joona-Pekko KAKKO, Henna PÄKKILÄ, Teemu KORPIMÄKI, Mikko SAIRANEN, Ville VEIKKOLAINEN
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Patent number: 11255861Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: GrantFiled: August 27, 2019Date of Patent: February 22, 2022Assignee: Wallac OyInventors: Pertti Hurskainen, Heikki Kouru, Mikko Sairanen, Tarja Ahola, Teemu Korpimäki
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Patent number: 11162955Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: GrantFiled: September 28, 2018Date of Patent: November 2, 2021Assignee: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20200033354Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: ApplicationFiled: August 27, 2019Publication date: January 30, 2020Applicant: Wallac OyInventors: Pertti HURSKAINEN, Heikki KOURU, Mikko SAIRANEN, Tarja AHOLA, Teemu KORPIMÄKI
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Patent number: 10444247Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: GrantFiled: September 11, 2015Date of Patent: October 15, 2019Assignee: Wallac OyInventors: Pertti Hurskainen, Heikki Kouru, Mikko Sairanen, Tarja Ahola, Teemu Korpimäki
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Publication number: 20190137508Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: September 28, 2018Publication date: May 9, 2019Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Patent number: 10119978Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: GrantFiled: March 15, 2013Date of Patent: November 6, 2018Assignee: WALLAC OYInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20180156815Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: February 1, 2018Publication date: June 7, 2018Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20160327563Abstract: A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.Type: ApplicationFiled: April 15, 2016Publication date: November 10, 2016Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Patent number: 9012201Abstract: A biological component enrichment unit for the isolation, purification and/or determination of a biological component using particles (3) and/or another solid phase, which enrichment unit comprises at least one sample container (1, 15, 26, 32, 39) for the realization of the biological sample method. The enrichment unit comprises a lead-through structure (5), such as a bushing (21, 27) made up of one or several parts or a cover having one or several openings (25, 36). The lead-through structure and one or several sample containers can be brought into connection with one another so that, when the lead-through structure is placed on top of the sample container, a functional unit is formed for the realization of the biological method, such as for the binding of the component, the growing, isolation, purification, enrichment of the bacteria or cell or for another similar method.Type: GrantFiled: December 4, 2006Date of Patent: April 21, 2015Assignee: BioControl Systems, Inc.Inventors: Matti Korpela, Tytti Miettinen, Tuija Tenhunen, Teemu Korpimäki, Pekka Mattsson, Mika Tuomola
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Publication number: 20140273025Abstract: A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20140273024Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20110300558Abstract: Thus this invention relates to a nanoparticle, useful for bioaffinity assays. The nanoparticle has a self-assembling shell built up of several protein and/or peptide subunits, which protein and/or peptide subunits can be of one or several different types, assembled in an organized manner to form the shell having an inner surface facing the inside and an outer surface facing the outside of said particle. One or several of the types of subunits have one or several first binding moieties per type of subunit with the binding moiety facing the outside of the particle for binding of any specific ligand binding protein; and the particle contains within its shell a marker and/or one or several of the types of subunits have one or several second binding moieties per type of subunit with the binding moiety facing the inside and/or the outside of the particle for binding a marker; and the marker or markers enables detection of the particle.Type: ApplicationFiled: July 29, 2011Publication date: December 8, 2011Inventors: Tero Soukka, Teemu Korpimäki, Urpo Lamminmäki, Marko Virta
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Publication number: 20110294227Abstract: The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably P1GF-2 and P1GF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations.Type: ApplicationFiled: November 20, 2009Publication date: December 1, 2011Applicants: PERKINELMER HEALTH SCIENCES, INC., WALLAC OY, NTD LABORATORIES, INC.Inventors: Tarja Ahola, Heini Frang, Teemu Korpimäki, Pertti Hurskainen, Mark N. Bobrow, Jonathan B. Carmichael
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Patent number: 7754473Abstract: A method for rapid thermal control of a reaction volume from a preceding temperature to a target temperature includes first bringing at least the reaction vessel's second wall, which has high thermal conductivity, into direct contact with a first thermal block at a temperature higher than the target temperature if the target temperature is higher than the preceding temperature, or at a temperature lower than the target temperature if the target temperature is lower than the preceding temperature, until the reaction volume temperature is at least close to the target temperature; and then bringing the second wall into direct contact with a second thermal block at the target temperature. Also disclosed is a system (20) for detecting and/or quantitating a biological and/or chemical analyte in a sample and a software product for the system.Type: GrantFiled: June 3, 2005Date of Patent: July 13, 2010Assignee: Abacus Diagnostica OyInventors: Jussi Nurmi, Teemu Korpimäki, Timo Lövgren, Hannu Kojola, Antti Iitia
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Publication number: 20090311733Abstract: A biological component enrichment unit for the isolation, purification and/or determination of a biological component using particles (3) and/or another solid phase, which enrichment unit comprises at least one sample container (1, 15, 26, 32, 39) for the realisation of the biological sample method. The enrichment unit comprises a lead-through structure (5), such as a bushing (21, 27) made up of one or several parts or a cover having one or several openings (25, 36). The lead-through structure and one or several sample containers can be brought into connection with one another so that, when the lead-through structure is placed on top of the sample container, a functional unit is formed for the realisation of the biological method, such as for the binding of the component, the growing, isolation, purification, enrichment of the bacteria or cell or for another similar method.Type: ApplicationFiled: December 4, 2006Publication date: December 17, 2009Inventors: Matti Korpela, Tytti Miettinen, Tuija Tenhunen, Teemu Korpimäki, Pekka Mattsson, Mika Tuomola