Patents by Inventor Teepu Siddique

Teepu Siddique has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular targets for ALS and related disorders
    Patent number: 11041205
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: June 22, 2021
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20200002767
    Abstract: Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms of SQSTM1.
    Type: Application
    Filed: February 8, 2019
    Publication date: January 2, 2020
    Inventors: Teepu Siddique, Faisal Fecto
  • SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20170260587
    Abstract: Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms of SQSTM1.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 14, 2017
    Inventors: Teepu Siddique, Faisal Fecto
  • Small molecule inhibitors of superoxide dismutase expression
    Patent number: 9669014
    Abstract: Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors which may be administered in methods of treating diseases or disorders associated with elevated SOD expression or activity, including neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS).
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 6, 2017
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Thomas J. Lukas, Hasan Arrat, Gary E. Schiltz
  • Allelic disorders caused by mutations in TRPV4
    Patent number: 9624544
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: April 18, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION
    Publication number: 20160214969
    Abstract: Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors which may be administered in methods of treating diseases or disorders associated with elevated SOD expression or activity, including neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: March 29, 2016
    Publication date: July 28, 2016
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Thomas J. Lukas, Hasan Arrat, Gary E. Schiltz
  • ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4
    Publication number: 20160102356
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Application
    Filed: December 17, 2015
    Publication date: April 14, 2016
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS
    Publication number: 20160076102
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 17, 2016
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • Allelic disorders caused by mutations in TRPV4
    Patent number: 9228236
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: January 5, 2016
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • Molecular targets for ALS and related disorders
    Patent number: 9173897
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: November 3, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION
    Publication number: 20150210679
    Abstract: Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors which may be administered in methods of treating diseases or disorders associated with elevated SOD expression or activity, including neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: January 28, 2015
    Publication date: July 30, 2015
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Thomas J. Lukas, Hasan Arrat
  • SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20130209999
    Abstract: Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms of SQSTM1.
    Type: Application
    Filed: August 17, 2012
    Publication date: August 15, 2013
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Faisal Fecto
  • Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4
    Patent number: 8394589
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: March 12, 2013
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS
    Publication number: 20120141459
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Application
    Filed: December 7, 2011
    Publication date: June 7, 2012
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4
    Publication number: 20110151445
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Application
    Filed: December 21, 2010
    Publication date: June 23, 2011
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • &agr;-Tocopherol transport protein: compositions and methods
    Patent number: 6268170
    Abstract: The present invention provides an isolated and purified &agr;-tocopherol transport protein polypeptide. Human recombinant &agr;-tocopherol transport protein, polynucleotides encoding human &agr;-tocopherol transport protein and methods of using &agr;-tocopherol transport protein polypeptides and polynucleotides are also provided.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: July 31, 2001
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Afif Hentati, Han-Xiang Deng