Patents by Inventor Teizo Yoshimura

Teizo Yoshimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of discoidin domain receptor 1 (DDR1) and agents that affect the DDR1/collagen pathway
    Patent number: 7855076
    Abstract: The disclosure provides methods of modulating the activity of DDR1. Methods for screening for agents that activate DDR1 are disclosed. Methods for inducing the maturation of immature macrophages and immature dendritic cells are also disclosed. In addition, methods for increasing neutrophil activation using a DDR1 activating agent, and methods for increasing leukocyte migration using a DDR1 activating agent, are provided.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: December 21, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Teizo Yoshimura, Hidenobu Kamohara
  • Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
    Patent number: 7319091
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: January 15, 2008
    Assignee: The United States of America as represented by the Secretary Department of Health and Human Services
    Inventors: Teizo Yoshimura, Elizabeth A. Robinson, Ettore Appella, Edward J. Leonard
  • Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
    Publication number: 20070270329
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
    Type: Application
    Filed: February 8, 2005
    Publication date: November 22, 2007
    Applicants: THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Teizo Yoshimura, Elizabeth Robinson, Ettore Appella, Edward Leonard
  • Use of discoidin domain receptor 1 (ddr1) and agents that affect the ddr1/collagen pathway
    Publication number: 20050118170
    Abstract: The disclosure provides methods of modulating the activity of DDR1. Methods for screening for agents that activate DDR1 are disclosed. Methods for inducing the maturation of immature macrophages and immature dendritic cells are also disclosed. In addition, methods for increasing neutrophil activation using a DDR1 activating agent, and methods for increasing leukocyte migration using a DDR1 activating agent, are provided.
    Type: Application
    Filed: December 11, 2002
    Publication date: June 2, 2005
    Inventor: Teizo Yoshimura
  • Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
    Patent number: 6869924
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: March 22, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Teizo Yoshimura, Elizabeth A. Robinson, Ettore Appella, Edward J. Leonard
  • Neutrophil chemotactic factor cloned cDNA and monoclonal antibodies thereto
    Patent number: 6475741
    Abstract: An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: November 5, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Novel neutrophil chemotactic factor cloned cDNA and monoclonal antibodies thereto
    Publication number: 20020151706
    Abstract: An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 17, 2002
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Nucleic acids encoding a novel neutrophil chemotactic factor
    Patent number: 6376659
    Abstract: An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity of NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: April 23, 2002
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Human derived monocyte attracting purified peptide products useful in a method of treating infection and neoplasms in a human body
    Patent number: 6090795
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with the peptide products are additionally provided, as well as pharmaceutical compositions for the peptide products.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: July 18, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Teizo Yoshimura, Elizabeth A. Robinson, Ettore Appella, Edward J. Leonard
  • Method of treating inflammation with antibodies to neutrophil chemotactic factor
    Patent number: 5925352
    Abstract: An isloated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: July 20, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body
    Patent number: 5714578
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 3, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Teizo Yoshimura, Elizabeth A. Robinson, Ettore Appella, Edward J. Leonard
  • Antibodies specific for neutrophic chemotactic factor
    Patent number: 5698196
    Abstract: The present invention relates to an isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete coding sequence for NCF.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Neutrophil chemotactic factor
    Patent number: 5652338
    Abstract: An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: July 29, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard, Joost Oppenheim, Ettore Appella, Stephen D. Showalter
  • Process for preparing human derived monocyte attracting purified peptide products useful in a method of treating infection and neoplasms in a human body
    Patent number: 5532144
    Abstract: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with the peptide products are additionally provided, as well as pharmaceutical compositions for the peptide products.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 2, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Teizo Yoshimura, Elizabeth A. Robinson, Ettore Appella, Edward J. Leonard
  • Antibodies to macrophage stimulating protein, bioassay and immunopurification method
    Patent number: 5527685
    Abstract: A method of purifying macrophage stimulating protein. Antibodies to macrophage stimulating protein and a bioassay for the detection of antibodies which bind macrophage stimulating protein.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: June 18, 1996
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Edward J. Leonard, Alison H. Skeel, Teizo Yoshimura, Ettore Appela
  • Process for producing a human neutrophil chemotactic factor peptide and a recombinant expression vector for the said polypeptide
    Patent number: 5306627
    Abstract: An expression vector in which a DNA encoding a human neutrophil chemotactic factor polypeptide is inserted, a transformant (a host cell transformed with the expression vector), and a process for production of the said polypeptide by using the said transformant.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: April 26, 1994
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Masaaki Yamada, Ryuji Furuta, Junichi Yamagishi, Kouji Matsushima, Teizo Yoshimura