Patents by Inventor Tejal A. Desai
Tejal A. Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230287072Abstract: The present disclosure provides a method of delivery, treatment, and prevention of neuropathy and/or pain associated with NGF treatment for an underline disease or condition with a NGF mutant, such as NGFR100W, that does not elicit pain. The present disclosure further provides a composition of micro- and/or nano-rods attached with the NGF mutant, such as NGFR100W, which are injectable or administered to a target for desired therapies.Type: ApplicationFiled: August 2, 2021Publication date: September 14, 2023Applicants: The Regents of the University of California, The Steadman Clinic & Steadman Philippon Research InstituteInventors: Chengbiao WU, Kijung SUNG, Chelsea Shileds BAHNEY, Kevin RIVERA, Tejal DESAI
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Publication number: 20220152152Abstract: The present disclosure is related to methods for stimulating bone fracture healing, comprising administering a pharmaceutical composition comprising biomaterial carriers comprising painless nerve growth factor (NGF).Type: ApplicationFiled: November 17, 2021Publication date: May 19, 2022Inventors: Chelsea BAHNEY, Tejal DESAI, Kevin RIVERA, Chengbiao WU
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Patent number: 11278626Abstract: Aspects of the present disclosure include compositions having a plurality of individual polymeric nanowires. Individual polymeric nanowires according to embodiments include a bioactive compound. Methods for preparing and methods for administering the subject compositions of individual polymeric nanowires to a subject are also described. Kits having one or more components for practicing the subject methods are also provided.Type: GrantFiled: October 4, 2017Date of Patent: March 22, 2022Assignee: The Regents of the University of CaliforniaInventors: Colin R. Zamecnik, Tejal A. Desai
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Patent number: 11185498Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: GrantFiled: March 11, 2020Date of Patent: November 30, 2021Assignee: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Publication number: 20210275588Abstract: The present disclosure provides polymeric particles comprising biomolecules of interest attached thereto, methods for using the same, and methods for making the same. The surface of the polymeric particles can be functionalized by attaching multiple different biomolecules of interest in a desired ratio for co-presentation. In addition, the polymeric particles may also encapsulate bio-molecules, such as, therapeutic nucleic acids, peptide and/or polypeptides for release in vivo. The present disclosure also provide synthetic particles and methods for enhancing proliferation of CAR-T cells. Additionally, the present disclosure provide biomolecule-coated films and methods.Type: ApplicationFiled: July 9, 2019Publication date: September 9, 2021Inventors: Tejal A. Desai, Xiao Huang, Ryan Chang, Jasper Z. Williams, Wendell A. Lim
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Patent number: 11033640Abstract: The present invention provides particulate contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation based on particles of low-Z elements selected from microparticles and nanoparticles. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. The invention also provides methods for imaging of body parts simultaneously enhanced with contrast media of the invention and with other contrast media of a different type using CT imaging, including dual energy or spectral CT imaging. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues, to generate multiple resultant CT images with individual contrast materials subtracted or highlighted.Type: GrantFiled: March 17, 2014Date of Patent: June 15, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Benjamin M. Yeh, Yanjun Fu, Tejal Desai
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Patent number: 11020345Abstract: Microdevices containing a chamber bound on one side by a nanoporous membrane are provided. The nanoporous membrane may contain hollow nanotubes that extend through the nanoporous membrane, from one surface to the other, and extend beyond the surface of the nanoporous membrane opposite the surface interfacing with the chamber. The nanotubes may provide a fluidic conduit between an environment external to the microdevice and the chamber, which is otherwise substantially fluid-tight. Also provided are methods of making a microdevice and methods of using the microdevices.Type: GrantFiled: March 14, 2017Date of Patent: June 1, 2021Assignee: The Regents of the University of California The Board of Trustees of the Leland Stanford Junior University StanfordInventors: Cade B. Fox, Hariharasudhan Chirra Dinakar, Nicholas A. Melosh, Tejal A. Desai
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Publication number: 20210085915Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.Type: ApplicationFiled: December 3, 2020Publication date: March 25, 2021Inventors: Daniel A. LIM, Matthew Silvestrini, Tejal Desai
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Patent number: 10888688Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.Type: GrantFiled: October 1, 2018Date of Patent: January 12, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel A. Lim, Matthew Silvestrini, Tejal Desai
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Patent number: 10865378Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: GrantFiled: August 24, 2018Date of Patent: December 15, 2020Assignee: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Crystal Nyitray, Ryan Chang
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Patent number: 10864158Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: GrantFiled: April 12, 2012Date of Patent: December 15, 2020Assignee: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Publication number: 20200261357Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: ApplicationFiled: March 11, 2020Publication date: August 20, 2020Inventors: Tejal A. Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Publication number: 20200113861Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: ApplicationFiled: September 27, 2018Publication date: April 16, 2020Inventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai
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Patent number: 10596125Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.Type: GrantFiled: December 11, 2015Date of Patent: March 24, 2020Assignee: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
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Patent number: 10426871Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.Type: GrantFiled: October 2, 2017Date of Patent: October 1, 2019Assignees: The Regents of the University of California, The Penn State Research FoundationInventors: Tejal A. Desai, Ketul C. Popat, Craig A. Grimes
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Publication number: 20190125668Abstract: Microdevices containing a chamber bound on one side by a nanoporous membrane are provided. The nanoporous membrane may contain hollow nanotubes that extend through the nanoporous membrane, from one surface to the other, and extend beyond the surface of the nanoporous membrane opposite the surface interfacing with the chamber. The nanotubes may provide a fluidic conduit between an environment external to the microdevice and the chamber, which is otherwise substantially fluid-tight. Also provided are methods of making a microdevice and methods of using the microdevices.Type: ApplicationFiled: March 14, 2017Publication date: May 2, 2019Inventors: Cade B. Fox, Hariharasudhan Chirra Dinakar, Nicholas A. Melosh, Tejal A. Desai
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Publication number: 20190119462Abstract: Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.Type: ApplicationFiled: June 13, 2017Publication date: April 25, 2019Applicant: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Ryan Chang, Jasper Z. Williams
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Publication number: 20190093069Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.Type: ApplicationFiled: August 24, 2018Publication date: March 28, 2019Inventors: Tejal A. Desai, Crystal Nyitray, Ryan Chang
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Publication number: 20190030281Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.Type: ApplicationFiled: October 1, 2018Publication date: January 31, 2019Inventors: Daniel A. LIM, Matthew SILVESTRINI, Tejal DESAI
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Patent number: 10111847Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that fmd use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions fmd use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: GrantFiled: September 2, 2016Date of Patent: October 30, 2018Assignees: The Regents of the University of California, The Brigham and Women's Hospital, Inc.Inventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai