Patents by Inventor Tejal Desai
Tejal Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10111847Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that fmd use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions fmd use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: GrantFiled: September 2, 2016Date of Patent: October 30, 2018Assignees: The Regents of the University of California, The Brigham and Women's Hospital, Inc.Inventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai
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Patent number: 10099034Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.Type: GrantFiled: July 26, 2013Date of Patent: October 16, 2018Assignee: The Regents of the University of CaliforniaInventors: Daniel A. Lim, Matthew Silvestrini, Tejal Desai
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Publication number: 20180185549Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.Type: ApplicationFiled: October 2, 2017Publication date: July 5, 2018Inventors: Tejal A. Desai, Ketul C. Popat, Craig A. Grimes
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Patent number: 9903035Abstract: The present disclosure provides devices, systems and methods with applicability in the coating of surfaces, in particular three-dimensional surfaces, via anodization reactions. For example, the disclosed devices, systems and methods find use in the formation of microstructured or nanostructured layers, e.g., metal oxide microstructured or nanostructured layers, via anodization on a variety of devices including, e.g., medical devices. Devices modified with one or more microstructured or nanostructured layers are also provided.Type: GrantFiled: December 2, 2013Date of Patent: February 27, 2018Assignee: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Harald Nuhn
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Patent number: 9878137Abstract: A method of preparing a substantially planar microdevice comprising a plurality of reservoirs is provided. In general, the method comprises forming a plurality of microdevices comprising a plurality of reservoirs from a planar layer of a biocompatible polymer. The method also comprises depositing one or more bioactive agents into the reservoirs. The microdevice is configured to attach to a target tissue and release the bioactive agent in close proximity to the tissue.Type: GrantFiled: May 24, 2013Date of Patent: January 30, 2018Assignee: The Regents of the University of CaliforniaInventors: Tejal A Desai, Hariharasudhan D. Chirra
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Publication number: 20170360717Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.Type: ApplicationFiled: December 11, 2015Publication date: December 21, 2017Inventors: Tejal A. Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
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Publication number: 20170319529Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: ApplicationFiled: June 19, 2017Publication date: November 9, 2017Inventor: Tejal A. Desai
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Patent number: 9775932Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.Type: GrantFiled: March 17, 2008Date of Patent: October 3, 2017Assignees: The Regents of the University of California, The Penn State Research FoundationInventors: Tejal A. Desai, Ketal C. Popat, Craig A. Grimes
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Publication number: 20170216238Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that fmd use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions fmd use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: ApplicationFiled: September 2, 2016Publication date: August 3, 2017Inventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai
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Patent number: 9463177Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: GrantFiled: September 9, 2013Date of Patent: October 11, 2016Assignees: The Regents of the University of California, The Brigham and Women's Hospital, Inc.Inventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai
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Publication number: 20150322583Abstract: The present disclosure provides devices, systems and methods with applicability in the coating of surfaces, in particular three-dimensional surfaces, via anodization reactions. For example, the disclosed devices, systems and methods find use in the formation of microstructured or nanostructured layers, e.g., metal oxide microstructured or nanostructured layers, via anodization on a variety of devices including, e.g., medical devices. Devices modified with one or more microstructured or nanostructured layers are also provided.Type: ApplicationFiled: December 2, 2013Publication date: November 12, 2015Inventors: Tejal A. Desai, Harald Nuhn
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Publication number: 20150216829Abstract: Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g.Type: ApplicationFiled: September 9, 2013Publication date: August 6, 2015Applicant: The Regents of the University of CaliforniaInventors: Michael S. Conte, Charles N. Serhan, Tejal A. Desai
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Publication number: 20150202406Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.Type: ApplicationFiled: July 26, 2013Publication date: July 23, 2015Inventors: Daniel A. Lim, Matthew Silvestrini, Tejal Desai
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Publication number: 20150119807Abstract: A method of preparing a substantially planar microdevice comprising a plurality of reservoirs is provided. In general, the method comprises forming a plurality of microdevices comprising a plurality of reservoirs from a planar layer of a biocompatible polymer. The method also comprises depositing one or more bioactive agents into the reservoirs. The microdevice is configured to attach to a target tissue and release the bioactive agent in close proximity to the tissue.Type: ApplicationFiled: May 24, 2013Publication date: April 30, 2015Applicant: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Hariharasudhan D. Chirra
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Publication number: 20140276021Abstract: The present invention provides particulate contrast media for use in CT imaging. The contrast media are based on particles of low-Z elements. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising essentially water-insoluble particles of a material selected from microparticles and nanoparticles. Exemplary particles comprise a material comprising a plurality of atoms of an element with an atomic number from 6 to 52. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast medium is incorporated into a pharmaceutically acceptable vehicle in which the particles are suspended.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Inventors: Benjamin M. YEH, Yanjun FU, Tejal DESAI
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Publication number: 20140170204Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.Type: ApplicationFiled: April 12, 2012Publication date: June 19, 2014Applicant: The Regents of the University of CaliforniaInventors: Tejal A. Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance
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Patent number: 8591933Abstract: The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders.Type: GrantFiled: January 19, 2010Date of Patent: November 26, 2013Assignee: The Board of Trustees of the University of IllinoisInventors: Brenda Russell, Tejal A. Desai, Paul Goldspink
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Publication number: 20120114734Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.Type: ApplicationFiled: March 17, 2008Publication date: May 10, 2012Inventors: Tejal A. Desai, Ketal C. Popat, Craig A. Grimes
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Publication number: 20100318193Abstract: The present invention provides compositions including a cell contacting surface or film comprising nanotopography of nanofibers, nanotubes, nanochannels, microchannels or microwells, which are capable of enhancing or promoting cell differentiation or cell viability. The compositions are useful as medical implants, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants. The present invention also provides methods of treating a patient in need of such an implant.Type: ApplicationFiled: March 10, 2008Publication date: December 16, 2010Inventors: Tejal A. Desai, Sarah Tao, Michael Young, Henry J. Klassen
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Patent number: 7803574Abstract: This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, a method of administering a composition to a patient is disclosed which comprises providing a composition-eluting device, said composition-eluting device comprising at least a first surface and a plurality of nanostructures attached to the first surface, and introducing the composition-eluting device into the body of the patient.Type: GrantFiled: February 22, 2007Date of Patent: September 28, 2010Assignee: Nanosys, Inc.Inventors: Tejal Desai, R. Hugh Daniels, Vijendra Sahi