Abstract: Thrombectomy devices and associated methods and systems are disclosed herein. According to some embodiments, the present technology includes a thrombectomy device including a tubular member having a proximal end region configured to be disposed extracorporeally and a distal end region configured to be disposed at an intravascular treatment site. The tubular member can include a sidewall defining a lumen extending from the proximal end region to the distal end region, and a plurality of side openings in the sidewall in the distal end region. The thrombectomy device can further include at least one adjustable flap configured to at least partially cover a side opening of the plurality of side openings of the tubular member. The adjustable flap may have a first end coupled to the tubular member and a free second end.

Abstract: Treatment devices and associated methods and systems are disclosed herein. According to some embodiments, the present technology includes a treatment device including a tubular member having a proximal end region configured to be disposed extracorporeally and a distal end region configured to be disposed at an intravascular treatment site. The tubular member can include a sidewall defining a lumen extending from the proximal end region to the distal end region, and a plurality of side openings in the sidewall in the distal end region.

Abstract: Systems, devices, and methods for thrombectomy are disclosed herein. According to some embodiments, the present technology includes a method including disposing a medical device within a vessel at or adjacent a treatment site. The medical device can include a tubular member defining a lumen extending between a proximal portion and a distal portion of the tubular member, the tubular member having one or more side openings and a distal opening in the distal portion. The method can further include applying negative pressure to the tubular member, where the negative pressure is configured to transition the distal opening of the tubular member from an open configuration in which the distal opening is in fluid communication with the lumen to a closed configuration in which the distal opening is at least partially closed, thereby reducing fluid communication with the lumen.

Abstract: Systems and methods for removing obstructions from bodily lumens are disclosed herein. A device for removing an obstruction may comprise a tubular body defining a lumen fluidically coupled to a suction source. The device may further comprise an aspiration region comprising a plurality of sidewall openings in fluid communication with the lumen and a mechanical engagement region disposed distal to the aspiration region. The mechanical engagement region may comprise an expandable member configured to expand radially outward. In some aspects, the expandable member is integrally formed with the tubular body.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.

Abstract: A guidewire comprising: a core wire; an elongated member extending along a longitudinal axis and defining: an inner surface defining an inner lumen, a plurality of openings disposed along the elongated member, each opening extending from an outer surface of the elongated member towards the inner surface, a first locking recess extending through the elongated member from the outer surface to the inner surface, a second locking recess extending from the inner surface towards a second location on the outer surface, wherein the first locking recess and the second locking recess defines a locking channel; and a locking element disposed within the locking channel and affixed to the elongated member, the locking element defining an aperture configured to receive the core wire, wherein the locking element is configured to inhibit unintended proximal movement of the core wire along the longitudinal axis relative to the elongated member.

Abstract: Systems and methods for removing clots via aspiration are disclosed herein. A catheter includes an elongate body defining a lumen. The distal region includes a distal openings region, a proximal openings region and a thrombus interface region between the distal and the proximal openings regions. The distal and proximal openings regions each includes one or more openings in fluid communication with the lumen. In use, the catheter is positioned from a proximal side of the clot so that the distal openings region positioned at least partially distal of the clot and the proximal openings region positioned at least partially proximal of the clot. An aspiration catheter is positioned with its distal end at the proximal end of the clot. The clot is then withdrawn in the proximal direction with a combination of aspiration applied to one or more of the catheter or the aspiration catheter.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.

Abstract: Vasculature models and associated systems and methods are disclosed herein. In some embodiments, the model comprises a tube including a lumen extending therethrough, a synthetic thrombus including a magnetic component, and a magnetized member. The thrombus is sized to be positioned within the lumen, and the magnetized member is positioned peripheral to the thrombus such that a radially outward force is exerted on the thrombus via the magnetized member. The tube may be part of a network of tubes that generally resemble human neurovasculature.

Abstract: Vasculature models and associated systems and methods are disclosed herein. In some embodiments, the model comprises a tube including a lumen extending therethrough, a synthetic thrombus including a magnetic component, and a magnetized member. The thrombus is sized to be positioned within the lumen, and the magnetized member is positioned peripheral to the thrombus such that a radially outward force is exerted on the thrombus via the magnetized member. The tube may be part of a network of tubes that generally resemble human neurovasculature.