Abstract: The present disclosure relates to delivery platforms that specifically and efficiently direct payloads to skeletal muscle cells in a subject, in vivo. The delivery platforms disclosed herein include targeting ligands (such as compounds that have affinity for integrins, including alpha-v-beta-6) and pharmacokinetic/pharmacodynamic (PK/PD) modulators, to facilitate the delivery of payloads to cells, including to skeletal muscle cells. Suitable payloads for use in the delivery platforms disclosed herein include RNAi agents, which can be linked or conjugated to the delivery platforms, and when delivered in vivo, provide for the inhibition of gene expression in skeletal muscle cells. Pharmaceutical compositions that include the skeletal muscle cell delivery platform are also described, as well as methods of use for the treatment of various diseases and disorders where delivery of a therapeutic payload to a skeletal muscle cell is desirable.

Abstract: A method for increasing compositional uniformity of element Al in a titanium-alloy EB ingot includes the following preparation steps: formulating materials, pressing the materials into briquettes with a set shape, arranging the briquettes into an electrode rod material, and feeding the electrode rod material into a feeding chamber for EB melting. The method can effectively resolve such problems as falling, deviation, and blockage of the electrode rod material in the process of switching to a new electrode rod material during melting for EB ingots, and can significantly improve the stability and uniformity of feeding and melting control in the melting process for titanium-alloy EB ingots, thereby increasing the compositional uniformity of element Al in EB ingots.