Abstract: Changes on a chat client, such as one or more edits or retractions, and is characterized relative to an original chat string, and uploaded to a chat server for storage. The chat server combines the message change with at least a second change to the specific chat string uploaded from a different chat client. Responsive to a regeneration of the chat string on the chat client, the chat daemon downloads the combined message change from the chat server. The edits and retractions originating from the chat client and the edits and retractions originating from the second chat client are downloaded and applied to the specific chat string for display in the chat client.

Abstract: The disclosure provides screening methods to identify small molecule compounds that can promote single circulating tumor cells (CTCs) proliferation, or alternatively inhibit proliferation by CTCs, and uses thereof, including as treatment options for cancer.

Abstract: In an embodiment, a data collection method includes: collecting, by a data collection device, performance indicator data of a target device based on a collection periodicity; detecting change amplitude of the collected performance indicator data that is in a change detection window, where the change detection window includes multiple collection periodicities; and when it is detected that change amplitude of the performance indicator data that is in the change detection window is greater than or equal to a change detection threshold, sending the performance indicator data that is in the change detection window to a data analysis device.

Abstract: method data collection method includes: collecting, by a data collection device, performance indicator data of a target device based on a collection periodicity; detecting change amplitude of the collected performance indicator data that is in a change detection window, where the change detection window includes multiple collection periodicities; and when it is detected that change amplitude of the performance indicator data that is in the change detection window is greater than or equal to a change detection threshold, sending the performance indicator data that is in the change detection window to a data analysis device.

Abstract: Spliceosome mutations are described herein, including mutations in the PHF5A and SF3B1 subunits. This application also describes detecting the presence and/or absence of mutations in the spliceosome, as well as methods of diagnosing responsiveness to splice modulator treatment, methods of treating neoplastic disorders, and methods of monitoring or altering the treatment based on mutation status.

Abstract: Systems and methods are disclosed for the functional decomposition of the catalog domain and its sub-domains inside a global scale e-commerce system into respective software application services with dedicated data storage, so in order for the complex raw data of different nature or sub-domain that belongs to large catalogs to be easily accessed and read by online stores, it needs to be deciphered and derived by its domain specific computational process then materialized into appropriate real time content that can be directly obtained via software services and APIs by B2C and B2B websites instead having to utilize lots of computational power for every on line store page request to generate necessary real time content from the same raw catalog data that is administered by catalog managers. In the case of data that does not frequently change (i.e.