Abstract: Provided is a method, comprising: providing a solution of delaminated MXene material and a first ionic intercalant; and contacting the solution with a second ionic intercalant so as to exchange the first ionic intercalant and the second ionic intercalant so as to give rise to flocculated portions of the MXene material and a supernatant that comprises the first ionic intercalant and the second ionic intercalant. Also provided is a MXene dispersion, comprising a plurality of portions of single-layer and/or few-layer MXene dispersed in a solvent, the solvent comprising a first ionic intercalant and a second ionic intercalant. Also provided is a stable MXene dispersion, comprising a plurality of portions of single-layer and/or few-layer MXene dispersed in a solvent, the solvent comprising an ionic intercalant, the ionic intercalant optionally being present in supersaturated form.

Abstract: Provided herein are compounds and compositions for treating, managing or preventing coronaviral related diseases. In particular, provided herein are compounds which are inhibitors of SARS-CoV-2 main protease (Mpro), pharmaceutical compositions comprising such compounds, method for synthesizing such compounds and methods of using such compounds and compositions for the treatment, management or prevention of coronaviral related diseases.

Abstract: Methods for creating self-folding materials that change shape in response to grooves created in the surface of the materials and when exposed to a stimuli. A tailored computational design tool, digital fabrication platform and mold for use with the methods also are provided.

Abstract: The invention discloses a fusion protein and its preparation method for intermediate polypeptide of Semaglutide. The invention belongs to the technical field of genetic engineering and polypeptide preparation. The fusion protein comprises a fusion peptide, a protease cleavage site and a target main molecular sequence. By optimizing the fusion peptide sequence, changing the isoelectric point and hydrophilicity of the protein, the highest expression of the fusion protein is effectively increased to 13.1 g/L. Meanwhile, the properties of fusion protein are also improved, which is conducive to the development of subsequent extraction, enzyme digestion and purification processes. The yield of intermediate polypeptide after enzyme digestion is 3.62 g/L. The production cost of Semaglutide intermediate polypeptide Arg34GLP-1(9-37) is reduced from the source, which is conducive to industrial scale-up and suitable for industrial production.

Abstract: An array substrate, a method of manufacturing the array substrate, and a display device are provided. The array substrate includes: a transparent rigid base; light-emitting chips on the transparent rigid base, each light-emitting chip including a chip body and a pin coupled to the chip body, a light-exiting surface of the chip body facing towards the transparent rigid base, and the pin being on a side of the chip body facing away from the transparent rigid base; a driving wire layer on a side of the pin facing away from the transparent rigid base; and a driving chip structure on a side of the driving wire layer facing away from the transparent rigid base. The driving chip structure is coupled to pins of the plurality of light-emitting chips through the driving wire layer, and is used for provide driving signals for the light-emitting chips.

Abstract: A system and devices provide for accurate localization of orthopedic implants based on magnetic tracking approach (MTA) technology and without radiation. The system includes at least one magnetic beacon that is joined to an orthopedic screw/implant fixed to a patient's spine. A detector in the form of a magnetic sensor array detects the magnetic field from the beacon and produces an electrical signal in response thereto. A computer using a multi-objective magnetic location algorithm tracks the spatial position and movement of the beacon based on the electrical signal, and hence tracks the patient's spine.

Abstract: The present disclosure relates to a composition, a substrate and a preparation method of a light reflection layer. The composition comprises: a matrix material and an additive, the matrix material including a solvent, reactant molecules and a material with reflection function dispersed in the solvent, wherein the reactant molecules is capable of undergoing cross-linking reaction under a first preset condition, and include monomer molecules and/or prepolymer molecules; the additive including a filler material that is in the form of powder or microspheres, capable of being dispersed in the matrix material, and filled between the crosslinking points of any adjacent reactant molecules to block the crosslinking reaction of some adjacent reactant molecules under the first preset condition.

Abstract: The invention discloses a fusion protein and its preparation method for intermediate polypeptide of Semaglutide. The invention belongs to the technical field of genetic engineering and polypeptide preparation. The fusion protein comprises a fusion peptide, a protease cleavage site and a target main molecular sequence. By optimizing the fusion peptide sequence, changing the isoelectric point and hydrophilicity of the protein, the highest expression of the fusion protein is effectively increased to 13.1 g/L. Meanwhile, the properties of fusion protein are also improved, which is conducive to the development of subsequent extraction, enzyme digestion and purification processes. The yield of intermediate polypeptide after enzyme digestion is 3.62 g/L. The production cost of Semaglutide intermediate polypeptide Arg34GLP-1(9-37) is reduced from the source, which is conducive to industrial scale-up and suitable for industrial production.

Abstract: In accordance with an embodiment, a method applied to a first device connected to a second device includes: displaying a first interface comprising address information; receiving a first user operation; in response to the first user operation, identifying the address information to determine intent information, wherein the intent information indicates that a place represented by the address information is a destination for navigation; and sending the intent information to the second device, wherein the intent information is used by the second device to display a second interface, and the second interface is used to provide a user with a navigation service with the place represented by the address information as the destination.

Abstract: A process operable using a computerized system for providing one or more output images of the spinal region of a subject for which anatomical landmarks applicable for clinical assessment are labeled in a pre-trained neural network (120a,120b) for clinical assessment of malalignment of a spine of a subject, the computerized system (100a,100b) including an image data acquisition device (110a), a pre-trained neural network (120a,120b) and an output module (140a) operably interconnected together via a communication link, said process including the steps of (i) by an image data acquisition device (110a,), acquiring one or more data input sets indicative of the spinal region of a subject, wherein each data input set of the one or more data input sets is indicative of an optical image of said subject at one or more corresponding postures of the subject; (ii) in a pre-trained neural network (120a,120b), providing labels to anatomical landmarks of said one or more data input sets each of which is indicative of said op

Abstract: A method for establishing an end-to-end network connection includes obtaining, by a first node, super node information from a server, obtaining, by the first node, a network address translation (NAT) type of the first node, obtaining, by the first node, a NAT type of a to-be-connected second node from the server, determining, by the first node based on the NAT type of the first node and the NAT type of the second node, whether to use a relay node, and selecting, by the first node, the relay node from super nodes to establish a connection to the second node.

Abstract: Embodiments of this application provide a database task processing method, a hot and cold data processing method, a storage engine, a device, and a storage medium. In the embodiments of this application, a database storage engine is integrated with a machine learning model, involved data samples and used resources in training of the machine learning model are dynamically adjusted by sensing a load pressure of the database storage engine, and through data collection at a storage engine level and a design of a lightweight model, online updating is performed on a model based on a background task. In this way, effectiveness and availability that the database storage engine is integrated with the machine learning model are ensured, and an accuracy rate and a recall rate of a task execution result are improved.

Abstract: Embodiments of this application disclose a communication method and a related device. The method includes: A symmetric device listens on N local public ports, where N is a natural number greater than 1; and when the symmetric device receives a hole punching packet from the N local public ports, the symmetric device sends a response packet to a cone device based on the hole punching packet, so that the symmetric device establishes a communication connection to the cone device, where the hole punching packet is sent by the cone device, and the response packet carries a first network information mapping relationship. The cone device may directly communicate with the symmetric device, so that there is no need for a server having a data relay function, and costs of deploying the server are reduced.

Abstract: The present disclosure provides an encapsulating structure, a display substrate and a manufacturing method therefor, and a display apparatus. The encapsulating structure is used for encapsulating components, and includes: a first encapsulating layer configured to cover the components; and a second encapsulating layer stacked with the first encapsulating layer; the second encapsulating layer is located on the side of the first encapsulating layer away from the components, a surface of the second encapsulating layer facing the first encapsulating layer is in contact with a surface of the first encapsulating layer facing the second encapsulating layer, and a surface of the second encapsulating layer away from the first encapsulating layer is substantially parallel to a plane where the encapsulating structure is located.

Abstract: The present invention relates to a display gauge, particularly used in a cab of a motor vehicle. The display gauge comprises a display unit and a control unit, the display unit having a stationary warning zone, the control unit being connectable with different types of sensors to receive sensor signals, wherein the display gauge further comprises a coded selector that can be operated by a user, the selector being electrically connected to the control unit to transmit to the control unit a signal indicative of a type of a current sensor signal selected by the user, and the control unit controls display of the display unit according to a value of the current sensor signal, so that a state in which the value of the current sensor signal reaches a warning value range can be displayed through the warning zone regardless of the type of the sensor.

Abstract: A method for training a trajectory planning model, an apparatus, and computer storage medium are provided. The method may include: obtaining an image of a physical environment in which a vehicle is located via at least one sensor of the vehicle, the image including multiple objects surrounding the vehicle; obtaining a feature chart indicating multiple initial trajectory points of the vehicle in the image from a trajectory planning model based on the image; identifying the image to determine in the image a first area associated with a road object in multiple objects and a second area associated with a non-road object in the multiple objects; determining a planning trajectory point based on positional relationship of the multiple initial trajectory points with respect to the first area and the second area; and training a trajectory planning model based on the planning track point and the actual trajectory point of the vehicle.

Abstract: The present invention relates to a relation extraction system adapted to financial entities and fused with prior knowledge and a method thereof, the system at least comprising: a deep pretraining module, for training and generating a deep pretrained model for recognizing attributes of the financial entities; a keyword analyzing module, for extracting and outputting positional information and importance vectors of keywords in a Chinese finance-related text; an attention mechanism module, for encoding the positional information of the keywords to obtain attention masks, and inputting them with entity information into the deep pretrained model to acquire text feature vectors; and an optimal margin distribution model module, for predicting financial-entity relations based on the text feature vectors and the importance vectors.

Abstract: A wake-up circuit, a wake-up method and a non-transitory computer-readable storage medium are disclosed. The wake-up circuit includes a wake-up module (11) and a main control module (12). The wake-up module (11) is connected to a wake-up source and is configured to detect a wake-up signal sent by the wake-up source, and to forward the wake-up signal to the main control module (12), one or more wake-up sources being provided. The main control module (12) is connected to the wake-up module (11) and is configured to receive the forwarded wake-up signal, one main control modules (12) being provided.

Abstract: A light emitting substrate, comprising a base substrate, a retaining wall disposed on the base substrate, and a plurality of light emitting diodes. The retaining wall defines a plurality of partitions on the base substrate, and at least one light emitting diode is provided in at least one partition.

Abstract: The present disclosure relates to a photoresist composition, a method for preparing the same, and a patterning method. The photoresist composition includes: 1 wt % to 10 wt % of a photosensitizer; 10 wt % to 20 wt % of a phenolic resin; 0.1 wt % to 5.5 wt % of an additive; and 75 wt % to 88 wt % of a solvent, based on the total weight of the photoresist composition, in which the photosensitizer includes: 20 wt % to 70 wt % of a first photosensitive compound represented by formula (1), 20 wt % to 70 wt % of a second photosensitive compound represented by formula (2), and 1 wt % to 35 wt % of a third photosensitive compound represented by formula (3), based on the total weight of the photosensitizer. The photoresist composition of the present disclosure simultaneously guarantees high resolution and high sensitivity, and can meet actual production requirements.