Patents by Inventor Tennore M. Ramesh

Tennore M. Ramesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of neurodegenerative diseases using proteasome modulators
    Patent number: 7902185
    Abstract: Methods for modulating proteasome activity in a subject is provided. Proteasome activity is modulated by administering a therapeutically effective amount of proteasome modulating pharmacological agent to a subject. In a preferred embodiment, the proteasome modulating pharmacological agent is a protease inhibitor. In another aspect, a screening assay for detecting and identifying proteasome modulating pharmacological agents to modulate proteasome activity in a subject is also provided.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: March 8, 2011
    Assignee: ALS Therapy Development Foundation, Inc.
    Inventors: Tennore M. Ramesh, Sean Scott
  • Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
    Patent number: 7198946
    Abstract: The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: April 3, 2007
    Assignee: Pathologica, LLC
    Inventors: Laurence J. Marton, Tennore M. Ramesh, Sean Scott, Michael McGrath
  • Methods for monitoring and treating amyotrophic lateral sclerosis
    Publication number: 20030175832
    Abstract: The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.
    Type: Application
    Filed: November 18, 2002
    Publication date: September 18, 2003
    Inventors: Laurence J. Marton, Tennore M. Ramesh, Sean Scott, Michael McGrath
  • Method of identifying the function of a test agent
    Publication number: 20010046665
    Abstract: Disclosed is a method of identifying the function of a test compound by contacting a plurality of cells with the test compound. The plurality includes at least a first cell and a second cell of a different type than the first cell type. Expression of one or more genes in cells of the plurality is measured.
    Type: Application
    Filed: January 19, 2001
    Publication date: November 29, 2001
    Inventors: Thomas J. Powell, Stacey A. Minskoff, Kerry E. Quinn, Tennore M. Ramesh