Patents by Inventor Terence D. Butters

Terence D. Butters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9199935
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: December 1, 2015
    Assignee: Acetelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • Patent number: 8729099
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: May 20, 2014
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • Patent number: 7348000
    Abstract: A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation or in combination with bone marrow transplantation. Inhibitors of glycolipid synthesis include N-butyldeoxynojirimycin (NB-DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) or N-nonyldeoxynojirimycin (NN-DNJ). Glycolipid storage-related disorders include Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick C storage disease, GM1 gangliosidosis, genetic disorders in which neuronal glycolipid accumulation contributes to disease pathology.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: March 25, 2008
    Assignee: Actelion Pharmaceuticals Ltd
    Inventors: Raymond A. Dwek, Terence D. Butters, Mylvaganam Jeyakumar, Frances Mary Platt, David Priestman
  • Publication number: 20040097551
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: July 11, 2003
    Publication date: May 20, 2004
    Inventors: Terence D. Butters, Raymond A. Dwek, George WJ Fleet, Michael Glen Orchard, Frances Mary Platt
  • Publication number: 20020142985
    Abstract: A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation or in combination with bone marrow transplantation. Inhibitors of glycolipid synthesis include N-butyldeoxynojirimycin (NB-DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) or N-nonyldeoxynojirimycin (NN-DNJ). Glycolipid storage-related disorders include Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick C storage disease, GM1 gangliosidosis, genetic disorders in which neuronal glycolipid accumulation contributes to disease pathology.
    Type: Application
    Filed: October 19, 2001
    Publication date: October 3, 2002
    Inventors: Raymond A. Dwek, Terence D. Butters
  • Patent number: 6069235
    Abstract: A method is disclosed for modifying the carbohydrate moiety on glycoproteins to facilitate the structural and functional analysis of said glycoproteins such as by NMR spectroscopic analysis and crystallography which comprises treating glycoprotein-secreting mammalian cells having low endomannosidase activity under cell culture maintenance conditions with a glucosidase I inhibitor, and after secretion and purification, subsequent treatment of the active glycoprotein with endoglycosidase H to thereby provide a glycoprotein with a single GlcNAc residue at each glycosylation sequon. The preferred mammalian cells are CHO cells and the preferred glucosidase I inhibitor is N-butyl deoxynojirimycin.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: May 30, 2000
    Assignee: Monsanto Company
    Inventors: Simon J. Davis, Terence D. Butters, Gunilla B. Karlsson, Frances M. Platt, Martin L. Bryant, Raymond A. Dwek