Patents by Inventor Terence G. Oas

Terence G. Oas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative, high-throughput screening method for protein stability
    Patent number: 7413906
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: August 19, 2008
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Quantitative, high-throughput screening method for protein stability
    Patent number: 7148071
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: December 12, 2006
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Quantitative, high-throughput screening method for protein stability
    Publication number: 20040157266
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Application
    Filed: March 18, 2004
    Publication date: August 12, 2004
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald
  • Quantitative, high-throughput screening method for protein stability
    Patent number: 6734023
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: May 11, 2004
    Assignee: Duke University
    Inventors: Terence G. Oas, Sina Ghaemmaghami, Kendall D. Powell, Michael C. Fitzgerald