Patents by Inventor Terence Keenan

Terence Keenan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic isoxazole compounds
    Patent number: 10053467
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: August 21, 2018
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventors: Alan Kaplan, Terence Keenan, Andrew McRiner
  • THERAPEUTIC ISOXAZOLE COMPOUNDS
    Publication number: 20170204111
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 20, 2017
    Inventors: Alan Kaplan, Terence Keenan, Andrew McRiner
  • Therapeutic isoxazole compounds
    Patent number: 9650349
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: May 16, 2017
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventors: Alan Kaplan, Terence Keenan, Andrew McRiner
  • THERAPEUTIC ISOXAZOLE COMPOUNDS
    Publication number: 20150336941
    Abstract: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 26, 2015
    Inventors: Alan Kaplan, Terence Keenan, Andrew McRiner
  • Therapeutic Compounds
    Publication number: 20070203154
    Abstract: The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
    Type: Application
    Filed: February 27, 2007
    Publication date: August 30, 2007
    Inventors: Xianbo Zhou, Roderick Scott, Rusiko Bourtchouladze, Alan Kaplan, Terence Keenan, Andrew McRiner
  • Pyrrolinone-based peptidomimetics
    Patent number: 5770732
    Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: June 23, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph F. Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman, Alexander Pasternak
  • Pyrrolinone-based compounds
    Patent number: 5489692
    Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: February 6, 1996
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman