Patents by Inventor Terence O'Reilly

Terence O'Reilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of solid tumors with rapamycin derivatives
    Patent number: 8877771
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: November 4, 2014
    Assignee: Novartis Pharmaceuticals Corporation
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • Treatment of solid tumors with rapamycin derivatives
    Patent number: 8778962
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: July 15, 2014
    Assignee: Novartis Pharmaceuticals Corporation
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20140105895
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: December 19, 2013
    Publication date: April 17, 2014
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20130296359
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: June 27, 2013
    Publication date: November 7, 2013
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20130287769
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: June 27, 2013
    Publication date: October 31, 2013
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20130253000
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: May 14, 2013
    Publication date: September 26, 2013
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20130244951
    Abstract: The present invention is directed to the use of rapamycin derivatives for use in treating solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: May 14, 2013
    Publication date: September 19, 2013
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • Treatment of solid tumors with rapamycin derivatives
    Patent number: 8436010
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: May 7, 2013
    Assignee: Novartis Pharmaceuticals Corporation
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • Cancer treatment
    Patent number: 8410131
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent.
    Type: Grant
    Filed: February 18, 2002
    Date of Patent: April 2, 2013
    Assignee: Novartis Pharmaceuticals Corporation
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20130059877
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: February 23, 2012
    Publication date: March 7, 2013
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • Combination comprising N--4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent.
    Publication number: 20120283206
    Abstract: A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.
    Type: Application
    Filed: July 17, 2012
    Publication date: November 8, 2012
    Inventors: Christian Bruns, Elisabeth Buchdunger, Terence O'Reilly, Sandra Leta Siberman, Markus Wartmann, Gisbert Weckbecker
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20120283285
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: July 11, 2012
    Publication date: November 8, 2012
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
    Publication number: 20120214774
    Abstract: Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.
    Type: Application
    Filed: February 23, 2012
    Publication date: August 23, 2012
    Inventors: Heidi Lane, Terence O'Reilly, Jeanette Marjorie Wood
  • Cancer treatment with epothilones
    Patent number: 7875601
    Abstract: The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: January 25, 2011
    Assignee: Novartis AG
    Inventors: Terence O'Reilly, Markus Wartmann, Manuel Litchman, Pamela Cohen
  • p53 wild-type as biomarker for the treatment with mTOR inhibitors in combination with a cytotoxic agent
    Patent number: 7749698
    Abstract: Provided are biomarkers for determining the sensitivity of proliferative diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: July 6, 2010
    Assignee: Novartis AG
    Inventors: Iwan Beuvink, Anne Boulay, Heidi Lane, Terence O'Reilly, George Thomas
  • Combination comprising a signal transduction inhibitor and an epothilone derivative
    Patent number: 7723339
    Abstract: The present invention relates to a combination comprising N-{5-[4-(4-methyl-piperazino-methyl) -benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and an epothiione derivative; pharmaceutical composition comprising said combination; method of treatment comprising said combination; and commercial packages comprising said combination.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: May 25, 2010
    Assignee: Novartis AG
    Inventors: Ralf Brandt, Elisabeth Buchdunger, Carl-Henrik Heldin, Arne Östman, Kristian Pietras, Terence O'Reilly, John D Rothermel, Peter Traxler, Markus Wartmann
  • COMBINATION COMPRISING N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2-METHYLPHENYL)-4-(3-PYRIDYL)-2PYRIMIDINE-AMINE AND A CHEMOTHERAPEUTIC AGENT
    Publication number: 20090202541
    Abstract: A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.
    Type: Application
    Filed: April 14, 2009
    Publication date: August 13, 2009
    Inventors: Christian Bruns, Elisabeth Buchdunger, Terence O'Reilly, Sandra Leta Silberman, Markus Wartmann, Gisbert Weckbecker
  • Combination of Mtor Inhibitor and Antipolate Compound
    Publication number: 20090012105
    Abstract: Use of a combination of an mTOR inhibitor and an antifolate compound.
    Type: Application
    Filed: January 12, 2008
    Publication date: January 8, 2009
    Applicant: NOVARTIS AG
    Inventors: Heidi Lane, Terence O'Reilly
  • BIOMARKERS FOR SENSITIVITY OF PROLIFERATIVE DISEASES TO MTOR INHIBITORS
    Publication number: 20080214596
    Abstract: Disclosed is a method for determining the sensitivity of a proliferate disease in a subject to treatment with an mTOR inhibitor, comprising determining the level of expression and/or phosphorylation state of S6 in a sample derived from the subject, as well as related methods of treatment and uses.
    Type: Application
    Filed: May 13, 2008
    Publication date: September 4, 2008
    Inventors: Anne Boulay, Heidi Lane, Sauveur-Michel Maira, Terence O' Reilly
  • USE OF BISPHOSPHONATES FOR PAIN TREATMENT
    Publication number: 20080207565
    Abstract: A method for the treatment of pain, in particular antinociceptive or anti-allodynic treatment of pain, in a patient in need of such treatment, e.g. a patient with osteoporosis or osteopenia, a tumour patient or a patient suffering from an inflammatory disease, which comprises administering an effective amount of a bisphosphonate, e.g.
    Type: Application
    Filed: May 1, 2008
    Publication date: August 28, 2008
    Inventors: Alyson Fox, Jonathan Green, Terence O'Reilly, Laszlo Urban, Katharine Walker