Patents by Inventor Terence Oas

Terence Oas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative, high-throughput screening method for protein stability
    Publication number: 20070099305
    Abstract: In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method employs hydrogen exchange to estimate the stability of quantities of unpurified protein extracts, using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A method of quantitatively determining the stability of a test protein under native conditions is disclosed.
    Type: Application
    Filed: December 5, 2006
    Publication date: May 3, 2007
    Inventors: Terence Oas, Sina Ghaemmaghami, Kendall Powell, Michael Fitzgerald