Abstract: A first node can be selected as a target node, and a second node can be selected as a control to determine a performance limit associated with providing a service. A request for the service can be determined to be routed to the first node. A first indication of a first performance measurement associated with processing a first load by the first node can be received. A second indication of a second performance measurement associated with processing a second load by the second node can be received. A performance error of the first node can be determined based on the first performance measurement and the second performance measurement. The performance limit can be determined based on the performance error, and an action can be triggered based on the performance limit.

Abstract: Request routing in a network of computing devices. Back-end nodes associated with a request router send load reports to request routers. To select a back-end node for processing a request, a request router determines, based on the reports, estimated loads and corresponding errors of the estimated loads for respective nodes. A load balancing technique may be selected, based on the estimated loads and corresponding errors (e.g., round robin may be selected if the significance of an average error outweighs the difference between estimated load values for the nodes, or least estimated load may be selected of the difference between load values is greater than the average error). The selected technique is applied to choose one of the nodes to process the request. Load probability distribution may also be used for request routing, in combination with or separate from the selection based on the estimated loads.

Abstract: Request routing in a network of computing devices. Back-end nodes associated with a request router send load reports to the request router that makes routing determinations for request from clients based on the reports. To select a back-end node for processing a request, a request router determines, based on the reports and one or more factors, load probability distributions for each of a group of back-end nodes selected from available back-end nodes. A load value is then randomly selected for each back-end node in the group, based on the node's probability distribution. The node in the group with the least randomly-selected value is chosen to process the request.

Abstract: In one embodiment, a method for providing secure and flexible inter-program communication includes storing an ontology in a first data store, the ontology includes a plurality of business semantics for an application, a plurality of rules for storing data in a database, and a plurality of rules for displaying the data in a browser. The method further includes receiving a new data type to add to the database and updating the ontology to describe the new data type. Updating the ontology includes updating the plurality of rules for storing the new data type in the database and updating the plurality of rules for displaying the new data type in the browser. In response to updating the ontology, generating a new column for the new data type in the database and communicating the new data type for presentation in the browser.

Abstract: In one embodiment, a method for providing secure and flexible inter-program communication includes storing an ontology in a first data store, the ontology includes a plurality of business semantics for an application, a plurality of rules for storing data in a database, and a plurality of rules for displaying the data in a browser. The method further includes receiving a new data type to add to the database and updating the ontology to describe the new data type. Updating the ontology includes updating the plurality of rules for storing the new data type in the database and updating the plurality of rules for displaying the new data type in the browser. In response to updating the ontology, generating a new column for the new data type in the database and communicating the new data type for presentation in the browser.

Abstract: A bioreactor, including at least one rotating drum, a substrate on the drum whereon a biofilm may grow, a rotational device rotating the drum and substrate, and a harvesting device.

Abstract: The present invention relates to compositions comprising 1,2-dihydropiridin-2-one compounds and an immunoregulatory or anti-inflammatory agent. The compositions are useful for the prevention or the treatment of neurodegenerative diseases, for example demyelinating disorders.

Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

Abstract: The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —NHCO—, —CONH—, —SO0-2—, etc.

Abstract: The present invention relates to compositions comprising 1,2-dihydropiridin-2-one compounds and an immunoregulatory or anti-inflammatory agent. The compositions are useful for the prevention or the treatment of neurodegenerative diseases, for example demyelinating disorders.

Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally sbutituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

Abstract: This invention is directed to pharmaceutical compositions and methods for treating demyelinating disorders based upon inhibitors of the interaction of glutamate with the AMPA and of the interaction of glutamate with the kainite receptor complex.

Abstract: This invention is directed to pharmaceutical compositions and methods for treating demyelinating disorders based upon inhibitors of the interaction of glutamate with the AMPA and of the interaction of glutamate with the kainite receptor complex.

Abstract: This invention is directed to pharmaceutical compositions and methods for treating demyelinating disorders based upon inhibitors of the interaction of glutamate with the AMPA and of the interaction of glutamate with the kainate receptor complex.

Abstract: The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.

Abstract: Layers of overburden are progressively removed from one inclined side of a cut by a rotating cutter and deposited on the other side of the cut in substantially the same geological sequence by traversing the cutter along an arm sloping along the inclined side, conveying the removed overburden by the arm to the bottom of the cut, and depositing the overburden by an adjustable endless belt on the opposite sloping side. The arm is moved along the sloping side by self-propelled transport units at the top and bottom of that sloping side.

Abstract: A longwall mining machine traverses to and fro along an articulated track assembly which includes an armoured face conveyor and which is engaged by a driven pinion on the machine body to haul the machine along its path.