Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.

Abstract: A system and method are provided for capturing hearing characteristics from self-administered hearing tests or from professionally administered hearing tests, including loudness tolerance levels as at different sound frequencies, as an individualized audiological profile for automatically enhancing audio to complement and address as closely as possible an individual's hearing deficits. The user may self-administer a hearing test on a convenient personal apparatus, such as a smartphone. The system includes the ability for capturing an environment profile. The user's hearing is protected against harm in the enhanced audio setting while being provided with the option of a “enhanced hearing” experience. The invention is useful for any individual seeking an enhanced hearing experience, whether having hearing within normal range or hearing that is impaired. Thus the system is useful as a hearing aid.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.

Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: A method for making superconducting material useful for forming electrolytic devices comprising the steps of establishing multiple valve metal rods in a primary billet of a ductile material; working the primary billet to a series of reduction steps to form said valve metal rods into a plurality of elongated elements surrounded at least in part by the ductile material; cutting the elongated elements from step (b) and bundling the cut elements to form a secondary billet; working the secondary billet through a series of reduction steps followed by rolling to final thickness; removing the ductile material, whereby to leave valve metal elongated fibers; and sintering the elongated fibers from step (e) under vacuum.

Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.

Abstract: A method for providing logically-consistent computer file backups in an operating environment whose file backup provisions rely on application programs recognizing a freeze writes command but where the operating system also hosts programs that do not recognize such a command. The method intercepts a system level command issued during the backup process that signals the file system manager to flush write operations cached in memory and hold any subsequent write operations. (“Flush and Hold Writes”). File write operations are then monitored to find a quiescent period, which signals that all current file transactions are complete. Application level write operations are halted, preventing any further file transactions. The Flush and Hold Writes Command is then allowed to pass to the file system and volume manager so that these operation system components can flush to permanent storage any write operations that are cached in memory and hold any new write operations.

Abstract: A Nb3Al superconducting wire and method for fabricating the same wherein Nb and Al powders in combination, or Nb—Al alloy powders are encapsulated in a metal tube, preferably copper or copper-alloy (e.g., CuNi), and the resultant composite is processed by conventional means to fine wire. Multifilamentary composites are produced by rebundling of the powder-filled wires into metal tubes followed by conventional processing to wire of a desired size. It is required for the use of Nb and Al powders in combination that the Nb and Al powder particle size be less than 100 nm. In the use of Nb—Al alloy powders, it is preferred, but not required, that the powder particle size be similarly of a nanometer scale. The use of nanometer-scale powders is beneficial to wire fabrication, allowing the production of long wire piece-lengths. At final wire size, the wires produced by practice of the present invention are heat treated at temperatures below the melting point of copper (1083° C.

Abstract: A Nb3Al superconducting wire and method for fabricating the same wherein Nb and Al powders in combination, or Nb—Al alloy powders are encapsulated in a metal tube, preferably copper or copper-alloy (e.g., CuNi), and the resultant composite is processed by conventional means to fine wire. Multifilamentary composites are produced by rebundling of the powder-filled wires into metal tubes followed by conventional processing to wire of a desired size. It is required for the use of Nb and Al powders in combination that the Nb and Al powder particle size be less than 100 nm. In the use of Nb—Al alloy powders, it is preferred, but not required, that the powder particle size be similarly of a nanometer scale. The use of nanometer-scale powders is beneficial to wire fabrication, allowing the production of long wire piece-lengths. At final wire size, the wires produced by practice of the present invention are heat treated at temperatures below the melting point of copper (1083° C.

Abstract: Porous metal compacts suitable for use as electrodes are formed through the reduction of a metal billet consisting of multiple filaments of an appropriate valve metal, preferably tantalum, contained within, and spaced apart by, a ductile metal, preferably copper. The filaments are elongated and substantially parallel within the billet. The array of valve metal filaments within the billet is surrounded by a continuous layer of valve metal. This metal is preferably, but not necessarily, the same as that which forms the filaments. The valve metal layer preferably completely surrounds the filament array circumferentially and runs the full length of the filaments. The layer is separated from the array by the same ductile metal that serves to separate the filaments from each other. This same ductile metal forms the surface of the billet, preventing exposure of the valve metal layer.

Abstract: A method for producing a superconductor by partial inter diffusion of layers of metal under a diffusion heat treatment to provide a ductile beta phase alloy, along with undiffused metal layers to permit ease of extrusion and drawing to fine layer thickness. At some point in the reduction the layers are further diffused to give an alloy superconducting product which is optimal for the high field (5-9 T) of interest in contact with a non-superconducting layer. This optimal diffusion is preferably accomplished after a sufficient reduction such that the individual metal layers are 2.5-15 microns thick.