Patents by Inventor Teresa Broering

Teresa Broering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20210269511
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: September 16, 2020
    Publication date: September 2, 2021
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • Isoform specific soluble FMS-like tyrosine kinase (sFlt) binding agents and uses thereof
    Patent number: 10421812
    Abstract: Aspects of the present disclosure relate to binding agents (e.g., antibodies and antigen binding fragments) that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. In some embodiments, immunological assay methods utilizing isoform-specific antibodies or antigen binding fragments that bind sFlt1 isoforms are provided for assessing biological samples obtained from pregnant subjects, e.g., for purposes of evaluating preeclampsia status in the subject.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: September 24, 2019
    Assignee: University of Massachusetts
    Inventors: Teresa Broering, Colby Souders, Gregory Babcock, Naomi Boatright
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20180208643
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • Anti-SOD1 antibodies and uses thereof
    Patent number: 9663586
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: May 30, 2017
    Assignee: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • ISOFORM SPECIFIC SOLUBLE FMS-LIKE TYROSINE KINASE (SFLT) BINDING AGENTS AND USES THEREOF
    Publication number: 20160347843
    Abstract: Aspects of the present disclosure relate to binding agents (e.g., antibodies and antigen binding fragments) that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. In some embodiments, immunological assay methods utilizing isoform-specific antibodies or antigen binding fragments that bind sFlt1 isoforms are provided for assessing biological samples obtained from pregnant subjects, e.g., for purposes of evaluating preeclampsia status in the subject.
    Type: Application
    Filed: March 31, 2016
    Publication date: December 1, 2016
    Applicant: University of Massachusetts
    Inventors: Teresa Broering, Colby Souders, Gregory Babcock, Naomi Boatright
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20160152694
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: October 29, 2015
    Publication date: June 2, 2016
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 9217029
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 22, 2015
    Assignees: UNIVERSITY OF MASSACHUSETTS, E. R. SQUIBB & SONS, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • ANTI-SOD1 ANTIBODIES AND USES THEREOF
    Publication number: 20150322167
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 12, 2015
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna AMBROSINO, Gregory BABCOCK, Teresa BROERING, Zuoshang XU
  • Anti-SOD1 antibodies and uses thereof
    Patent number: 9109037
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: August 18, 2015
    Assignee: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) AND USES THEREOF
    Publication number: 20140134175
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Application
    Filed: September 24, 2013
    Publication date: May 15, 2014
    Inventors: Donna M. AMBROSINO, William D. THOMAS, JR., Gregory J. BABCOCK, Teresa BROERING, Susan SLOAN
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20140120614
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 1, 2014
    Applicants: MEDAREX, L.L.C., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • ANTI-SOD1 ANTIBODIES AND USES THEREOF
    Publication number: 20140044722
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 13, 2014
    Applicant: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 8609111
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 17, 2013
    Assignees: University of Massachusetts, Medarex, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Human antibodies against hepatitis C virus (HCV) and uses thereof
    Patent number: 8551484
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: October 8, 2013
    Assignee: University of Massachusetts
    Inventors: Donna M. Ambrosino, William D. Thomas, Jr., Gregory J. Babcock, Teresa Broering, Susan Sloan
  • HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) AND USES THEREOF
    Publication number: 20120288510
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Application
    Filed: February 13, 2008
    Publication date: November 15, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna M. Ambrosino, William D. Thomas, JR., Gregory J. Babcock, Teresa Broering, Susan Sloan
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20120288508
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: June 7, 2012
    Publication date: November 15, 2012
    Applicants: MEDAREX, INC., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against toxins and uses thereof
    Patent number: 8257709
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: September 4, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 8236311
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: August 7, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20100233181
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: July 31, 2009
    Publication date: September 16, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, MEDAREX, INC.
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against Clostridium difficile toxins and uses thereof
    Publication number: 20100233182
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: July 31, 2009
    Publication date: September 16, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, MEDAREX, INC.
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG