Patents by Inventor Teresa Di Colandrea

Teresa Di Colandrea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selectable gene marker system based on expression of N-acetyllactosaminide 3-? galactosyltransferase
    Patent number: 7078179
    Abstract: A method is described for the rapid identification and isolation of cells based on the presence or absence of an ectopically-expressed N-acetyllactosaminide 3-? Galactosyltransferase (?GT) enzyme for the production of ?Galactosyl-(1,3)Galactosyl (?Gal) epitopes on the surface of ?Gal-negative cells. These cells which are genetically modified to express the ?GT enzyme and ?Gal epitopes on glycosylated lipids and proteins of the cell surface are then labeled via an antibody composition which recognizes and binds the ?Gal epitopes on the cell surface. Cells labeled with the anti-?Gal antibody can be isolated by sorting via fluorescence activated cell sorting (FACS), or by magnetic panning techniques. This method is suitable for the rapid positive or negative selection of ?Gal-positive cells from within a population of ?Gal-negative cells without the need to expose cells to antibiotics for any period of time.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: July 18, 2006
    Assignee: Newlink Genetics Corporation
    Inventors: Teresa Di Colandrea, Cherisa Meyer, Won-Bin Young, James N. Higginbotham, Mario Mautino, Charles J. Link, Jr.
  • Selectable gene marker system based on expression of N-acetyllactosaminide 3-alpha galactosyltransferase
    Publication number: 20050250107
    Abstract: A method is described for the rapid identification and isolation of cells based on the presence or absence of an ectopically-expressed N-acetyllactosaminide 3-? Galactosyltransferase (?GT) enzyme for the production of ?Galactosyl-(1,3)Galactosyl (?Gal) epitopes on the surface of ?Gal-negative cells. These cells which are genetically modified to express the ?GT enzyme and ?Gal epitopes on glycosylated lipids and proteins of the cell surface are then labeled via an antibody composition which recognizes and binds the ?Gal epitopes on the cell surface. Cells labeled with the anti-?Gal antibody can be isolated by sorting via fluorescence activated cell sorting (FACS), or by magnetic panning techniques. This method is suitable for the rapid positive or negative selection of ?Gal-positive cells from within a population of ?Gal-negative cells without the need to expose cells to antibiotics for any period of time.
    Type: Application
    Filed: May 4, 2004
    Publication date: November 10, 2005
    Applicant: Newlinks Genetics Corporation
    Inventors: Teresa Di Colandrea, Cherisa Meyer, Won-Bin Young, James Higginbotham, Mario Mautino, Charles Link