Abstract: A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

Abstract: A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

Abstract: A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

Abstract: A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

Abstract: Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Abstract: Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.