Patents by Inventor Teresa H. Ho

Teresa H. Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
    Patent number: 6051686
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 18, 2000
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Jr., Teresa H. Ho, Brian H. Vickery, Chinh T. Bach
  • Synthesis and use for the treatment of osteoporosis
    Patent number: 5874086
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: February 23, 1999
    Assignee: Syntex (U.S.A,), Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Teresa H. Ho, Brian H. Vickery, Chinh T. Bach
  • Analogs of parathyroid hormone and parathyroid hormone relate peptide synthesis and use for the treatment of osteoporosis
    Patent number: 5840837
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: November 24, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Teresa H. Ho
  • Process for recombinant production of PTH and PTHrp analogs
    Patent number: 5798225
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: August 25, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Teresa H. Ho, Brian H. Vickery, Chinh T. Bach
  • C-reactive protein fragment with immunomodulatory activity
    Patent number: 5783179
    Abstract: Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: July 21, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John J. Nestor, Jr., Teresa H. Ho, Deborah A. Eppstein, Philip L. Felgner, Barbara P. Barna, Sharad D. Deodhar
  • Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
    Patent number: 5695955
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, these residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa (Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 9, 1997
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Jr., Teresa H. Ho, Brian H. Vickery, Chinh T. Bach
  • Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
    Patent number: 5589452
    Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa).sub.2 Laaand their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: December 31, 1996
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John L. Krstenansky, John J. Nestor, Jr., Teresa H. Ho, Brian H. Vickery, Chinh T. Bach