Patents by Inventor Teresa K. Woodruff

Teresa K. Woodruff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Zinc-responsive fluorophores
    Patent number: 11953435
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: April 9, 2024
    Assignee: Northwestern University
    Inventors: Seth A. Garwin, Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • Multi-chamber fluidic platform
    Patent number: 11926814
    Abstract: Provided herein are systems comprising multiple fluidically-coupled chamber volumes. In particular, provided herein are cell culture systems that incorporate fluid flow between multiple cell culture volumes, and method of use thereof for the culture of multiple related cell/tissue types.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 12, 2024
    Assignee: Northwestern University
    Inventors: Hunter B. Rogers, Teresa K. Woodruff
  • 3D microphysiologic system
    Patent number: 11542475
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: January 3, 2023
    Assignees: The Board of Trustees of the University of Illinois, Northwestern University
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • Compositions and methods for the detection of zinc
    Patent number: 11448644
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: September 20, 2022
    Assignee: Northwestern University
    Inventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt
  • TISSUE CULTURE PLATFORM HAVING MULTIPLE WELL CHAMBERS FLUIDICALLY COUPLED VIA MICROFLUIDIC CHANNELS AND SELECTOR VALVES
    Publication number: 20220025308
    Abstract: Tissue culture platforms that may be configured for tissue culture or biological cell culture, and methods for use thereof, are described. In general, the tissue culture platforms include multiple well chambers that are fluidically coupled by one or more channels Flow between the different well chambers is controlled via one or more selector valves, enabling a single tissue culture platform that can provide multiple integrated culture subsystems, multiple non-interacting culture subsystems, or combinations thereof.
    Type: Application
    Filed: October 16, 2019
    Publication date: January 27, 2022
    Inventors: Hunter B. Rogers, Teresa K. Woodruff
  • Compositions and methods for the detection of zinc
    Patent number: 11125741
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: September 21, 2021
    Assignee: Northwestern University
    Inventors: Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • ZINC-RESPONSIVE FLUOROPHORES
    Publication number: 20210096076
    Abstract: Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Inventors: Seth A. Garwin, Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • Multi-Chamber Fluidic Platform
    Publication number: 20200224147
    Abstract: Provided herein are systems comprising multiple fluidically-coupled chamber volumes. In particular, provided herein are cell culture systems that incorporate fluid flow between multiple cell culture volumes, and method of use thereof for the culture of multiple related cell/tissue types.
    Type: Application
    Filed: August 21, 2018
    Publication date: July 16, 2020
    Applicant: Northwestern University
    Inventors: Hunter B. Rogers, Teresa K. Woodruff
  • 3D MICROPHYSIOLOGIC SYSTEM
    Publication number: 20200190479
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Application
    Filed: October 21, 2019
    Publication date: June 18, 2020
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC
    Publication number: 20200033326
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Application
    Filed: July 16, 2019
    Publication date: January 30, 2020
    Inventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt
  • 3D microphysiologic system
    Patent number: 10526578
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 7, 2020
    Assignees: Northwestern University, The Board of Trustees of the University of Illinois
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • Artificial ovary
    Patent number: 10479980
    Abstract: Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The artificial ovaries have spatial arrangements and cellular compositions that allow them to mimic native ovarian tissue. As such, they can be cultured or transplanted to support female endocrine function and/or the development of oocytes and/or eggs.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: November 19, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Monica M. Laronda, Alexandra L. Rutz, Ramille N. Shah, Teresa K. Woodruff
  • Compositions and methods for the detection of zinc
    Patent number: 10352925
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: July 16, 2019
    Assignee: Northwestern University
    Inventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt
  • COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC
    Publication number: 20190033299
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Application
    Filed: February 20, 2018
    Publication date: January 31, 2019
    Inventors: Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • 3D MICROPHYSIOLOGIC SYSTEM
    Publication number: 20180057796
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Application
    Filed: June 30, 2017
    Publication date: March 1, 2018
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • Compositions and methods for the detection of zinc
    Patent number: 9897595
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: February 20, 2018
    Assignee: Northwestern University
    Inventors: Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • ARTIFICIAL OVARY
    Publication number: 20170369851
    Abstract: Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The artificial ovaries have spatial arrangements and cellular compositions that allow them to mimic native ovarian tissue. As such, they can be cultured or transplanted to support female endocrine function and/or the development of oocytes and/or eggs.
    Type: Application
    Filed: January 28, 2016
    Publication date: December 28, 2017
    Inventors: Monica M. Laronda, Alexandra L. Rutz, Ramille N. Shah, Teresa K. Woodruff
  • 3D microphysiologic system
    Patent number: 9695399
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 4, 2017
    Assignees: Northwestern University, Board of Trustees of the University of Illinois
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • 3D MICROPHYSIOLOGIC SYSTEM
    Publication number: 20150252328
    Abstract: The present invention relates generally to a three-dimensional cell and tissue culture system for the female reproductive tract. In particular provided herein the system includes individual female reproductive cultures in a dynamic microfluidic setting or integrated using a microfluidic microphysiologic system. In some embodiments, the present invention provides ex-vivo female reproductive tract integration in a three dimensional (3D) microphysiologic system.
    Type: Application
    Filed: January 28, 2015
    Publication date: September 10, 2015
    Inventors: Teresa K. Woodruff, Ji-Yong Julie Kim, Joanna E. Burdette, Spiro Getsios, Sevim Yildiz Arslan, Shuo Xiao, Jie Zhu
  • COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC
    Publication number: 20150094524
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 2, 2015
    Inventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt