Patents by Inventor Teresa L. Wright

Teresa L. Wright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating phenylketonuria
    Patent number: 11952585
    Abstract: Provided herein are methods of treating a subject having a disease or disorder associated with a PAH gene mutation. The methods generally comprise administering to the subject a therapeutically effective does of a recombinant adeno-associated virus (rAAV) that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell and thereby restore PAH gene function in the subject.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: April 9, 2024
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Omar L. Francone, Deborah A. Kinch, Diana Lamppu, Albert Barnes Seymour, Teresa Leah Wright
  • LIPID NANOPARTICLE FORMULATIONS OF NON-VIRAL, CAPSID-FREE DNA VECTORS
    Publication number: 20210059953
    Abstract: Provided herein are lipid nanoparticle formulations that comprise an ionizable lipid and non-viral, capsid-free DNA vectors with covalently-closed ends.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 4, 2021
    Inventors: Robert Michael Kotin, Ozan Alkan, Douglas Anthony Kerr, Ara Karl Malakian, Matthew John Simmons, Matthew G. Stanton, Jie Su, Teresa L. Wright
  • MODIFIED CLOSED-ENDED DNA (CEDNA)
    Publication number: 20200283794
    Abstract: CeDNA vectors having linear and continuous structure can be produced in high yields and used for effective transfer and expression of a transgene. ceDNA vectors comprise an expression cassette and two different ITR sequences derived from AAV genomes in a specified order. Some ceDNA vectors provided herein further comprise cis-regulatory elements and provide high gene expression efficiencies. Further provided herein are methods and cell lines for reliable and efficient production of the linear, continuous and capsid-free DNA vectors.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 10, 2020
    Inventors: Robert Michael Kotin, Ozan Alkan, Annaliese Jones, Douglas Anthony Kerr, Ara Karl Malakian, Matthew John Simmons, Teresa L. Wright