Abstract: A method for preparing ferrite nanoparticles employing as directing agent an aldehyde or ketone of formula R1—(C?O)R2 is provided. R1 is a linear or branched, saturated or unsaturated carbon chain having a length between 1 and 13 carbon atoms, optionally substituted with an aromatic substituent. R2 is selected from the group consisting of hydrogen, an aromatic ring and a linear or branched, saturated or unsaturated carbon chain having a length between 1 and 10 carbon atoms. When R2 is hydrogen and R1 is an unsaturated carbon chain substituted with an aromatic substituent, the aromatic substituent is located at position 3 or higher with respect to the carbonyl group —(C?O). When R2 is hydrogen and R1 is a saturated carbon chain substituted with an aromatic substituent, the aromatic substituent is located at position 2 or higher with respect to the carbonyl group —(C?O). When the aromatic substituent is located at position 2, the aromatic substituent is the sole substituent at position 2.

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

Abstract: Described herein is a method for producing ferrite nanocrystals. The method includes providing a solution including a fatty acid, an aliphatic amine and an alcoholic solvent, adding at least one organometallic precursor compound including a metal selected from the group consisting of Fe, Mn, Co and Zn and an aromatic organic molecule to the solution thereby obtaining a reaction mixture, transferring the reaction mixture to a sealed reactor, thereby obtaining a filling percentage of the sealed reactor between 20 and 70 vol. %, and heating the sealed reactor to a temperature between 160° C. and 240° C. for at least 3 hours.

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

Abstract: A heat-sensitive system comprising at least one nanoparticle bound covalently to at least one thermolabile molecule comprising an azo —N?N— functional group —N?N— in turn bound covalently to at least one active molecule selected from a fluorophore molecule and a drug is disclosed. The system converts an electromagnetic radiation into thermal energy exposed to an alternating magnetic field. Uses of the system are also disclosed.

Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a converting process and a separation process are performed to isolate a plurality of nanoparticles with a controlled number of the fifth active groups. The controlled number is integers from 0 to 10.

Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a separation process is performed to isolate a plurality of nanoparticles with a controlled number of the third active groups. The controlled number is integers from 0 to 10.

Abstract: Methods of making iron-based ferrite nanocrystals are provided. In such methods the ferrite may include iron oxides and iron/cobalt or iron/manganese mixed salts. The method may include thermal decomposition of one or more precursors of the ferrite, consisting of an organic salt of the metal or metals constituting the ferrite of interest, comprising the operation of heating a solution comprising said precursor(s) in the presence of a surfactant and of a non-aqueous organic solvent comprising an ether, at temperature sufficient to cause thermal decomposition of said precursor, wherein the solvent may further comprise a saturated or unsaturated, linear or branched aliphatic hydrocarbon, liquid at temperatures above 45° C. and having a boiling point above the boiling point of the ethereal solvent.

Abstract: A heat-sensitive system comprising at least one nanoparticle bound covalently to at least one thermolabile molecule comprising an azo —N?N— functional group —N?N— in turn bound covalently to at least one active molecule selected from a fluorophore molecule and a drug is disclosed. The system converts an electromagnetic radiation into thermal energy exposed to an alternating magnetic field. Uses of the system are also disclosed.

Abstract: Methods of making iron-based ferrite nanocrystals are provided. In such methods the ferrite may include iron oxides and iron/cobalt or iron/manganese mixed salts. The method may include thermal decomposition of one or more precursors of the ferrite, consisting of an organic salt of the metal or metals constituting the ferrite of interest, comprising the operation of heating a solution comprising said precursor(s) in the presence of a surfactant and of a non-aqueous organic solvent comprising an ether, at temperature sufficient to cause thermal decomposition of said precursor, wherein the solvent may further comprise a saturated or unsaturated, linear or branched aliphatic hydrocarbon, liquid at temperatures above 45° C. and having a boiling point above the boiling point of the ethereal solvent.

Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a separation process is performed to isolate a plurality of nanoparticles with a controlled number of the third active groups. The controlled number is integers from 0 to 10.