Patents by Inventor Teresa Szal

Teresa Szal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ribosomes with tethered subunits
    Patent number: 10590456
    Abstract: An engineered ribosome that includes a tethered subunit arrangement is disclosed, in which the engineered ribosome supports translation of a sequence defined polymer. Methods for making and using the engineered ribosome are also disclosed, including a method for preparing a sequence defined polymer using the engineered ribosome and a method for preparing a sequence defined polymer using the engineered ribosome in a two-protein translation system. The engineered ribosomes may be utilized in methods for incorporating unnatural amino acids into a sequence defined polymer. Also disclosed are optimized polynucleotide sequences for use as tethers and Shine-Dalgarno/anti-Shine-Dalgarno sequences.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 17, 2020
    Assignees: Northwestern University, The Board of Trustees of the University of Illinois
    Inventors: Michael Christopher Jewett, Do Soon Kim, Erik D. Carlson, Alexander S. Mankin, Cedric Orelle, Teresa Szal, Anne E. d'Aquino
  • RIBOSOMES WITH TETHERED SUBUNITS
    Publication number: 20170073381
    Abstract: An engineered ribosome that includes a tethered subunit arrangement is disclosed, in which the engineered ribosome supports translation of a sequence defined polymer. Methods for making and using the engineered ribosome are also disclosed, including a method for preparing a sequence defined polymer using the engineered ribosome and a method for preparing a sequence defined polymer using the engineered ribosome in a two-protein translation system. The engineered ribosomes may be utilized in methods for incorporating unnatural amino acids into a sequence defined polymer. Also disclosed are optimized polynucleotide sequences for use as tethers and Shine-Dalgarno/anti-Shine-Dalgarno sequences.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Applicant: Northwestern University
    Inventors: Michael Christopher Jewett, Do Soon Kim, Erik D. Carlson, Alexander S. Mankin, Cedric Orelle, Teresa Szal