Patents by Inventor Terete Borras

Terete Borras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Self-complementary AAV vectors carrying dominant negative RhoA and methods of use to treat ocular diseases
    Publication number: 20240100193
    Abstract: Provided herein are recombinant self-complementary adeno-associated virus (scAAV) nucleic acid vectors that comprise a ubiquitous eukaryotic promoter, such as elongation factor 1? (EF1?), chicken beta-actin (CBA), and hybrid chicken beta-actin (CBh), followed by a dominant negative RhoA. Also provided herein are methods of use of said vectors, including intraocular injections (e.g., intracameral injections) to reduce intra-ocular pressure (TOP). Also provided herein are plasmids, recombinant scAAV particles, compositions, formulations, and other methods of use related to such vectors.
    Type: Application
    Filed: September 15, 2023
    Publication date: March 28, 2024
    Inventors: Terete Borras, Guiying Hong, Bo Liang, Ling Wu, Carola Maturana