Patents by Inventor Terhi Heikkinen

Terhi Heikkinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10835515
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: November 17, 2020
    Assignee: ORION CORPORATION
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20190321333
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 24, 2019
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10383853
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 20, 2019
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10376494
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 13, 2019
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180280355
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180280354
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10010530
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: July 3, 2018
    Assignee: Orlon Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • A CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180008577
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 11, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • PHARMACOLOGICALLY ACTIVE QUINAZOLINEDIONE DERIVATIVES
    Publication number: 20170137387
    Abstract: Compounds of formula (I), wherein R1 through R8 are as defined in the claims, exhibit a positive allosteric GABAB modulator effect and are thus useful as positive allosteric modulators of the GABAB receptor.
    Type: Application
    Filed: May 8, 2015
    Publication date: May 18, 2017
    Inventors: Peteris PRUSIS, Iisa HÖGLUND, Olli TÖRMAKANGAS, Ari HIETANEN, Riina ARVELA, Anniina VESALAINEN, Terhi HEIKKINEN
  • N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists
    Patent number: 9533952
    Abstract: Compounds of formula I, wherein A, B, X, Z and R1-R6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: January 3, 2017
    Assignee: ORION CORPORATION
    Inventors: Riina Arvela, Terhi Heikkinen, Patrik Holm, Peteris Prusis, Mattias Roslund, Harri Salo
  • N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS
    Publication number: 20150376130
    Abstract: Compounds of formula I, wherein A, B, X, Z and R1-R6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators.
    Type: Application
    Filed: September 30, 2013
    Publication date: December 31, 2015
    Applicant: Orlon Corporation
    Inventors: Riina ARVELA, Terhi HEIKKINEN, Patrik HOLM, Peteris PRUSIS, Mattias ROSLUND, Harri SALO
  • Androgen receptor modulating carboxamides
    Patent number: 8921378
    Abstract: Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14?, R15, R15?, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: December 30, 2014
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Gerd Wohlfahrt, Harri Salo, Rathna Durga Ramasubramanian, Pranab Kumar Patra, Arputharaj Ebenezer Martin, Terhi Heikkinen, Anniina Vesalainen, Anu Moilanen, Arja Karjalainen
  • ANDROGEN RECEPTOR MODULATING CARBOXAMIDES
    Publication number: 20140094474
    Abstract: Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14?, R15, R15?, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
    Type: Application
    Filed: April 20, 2012
    Publication date: April 3, 2014
    Applicant: ORION CORPORATION
    Inventors: Olli Törmakängas, Gerd Wohlfahrt, Harri Salo, Rathna Durga Ramasurbamanian, Pranab Kumar Patra, Arputharaj Ebenezer Martin, Terhi Heikkinen, Anniina Vesalainen, Anu Moilanen, Arja Karjalainen