Patents by Inventor Terrence J. Andreasen
Terrence J. Andreasen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7291481Abstract: The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of these substrates by vaginal fluid at a low pH. Selective assays for trichomoniasis are also obtained by removing particulate matter from a sample of vaginal fluid to extract a fraction devoid of particles greater than a selected size, and where desired, combining the extracted fraction with any of certain specified hydrolase inhibitors, then testing the fraction for enzymatic hydrolase activity. These qualities of trichomoniasis are the basis for a series of diagnostic tests and test devices that produce results that are detectable by visual and other means with a high degree of accuracy.Type: GrantFiled: February 13, 2006Date of Patent: November 6, 2007Assignee: Quidel CorporationInventors: Paul J. Lawrence, Mark A. Hughes, Aulena Chaudhuri, Terrence J. Andreasen
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Patent number: 7041469Abstract: The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of these substrates by vaginal fluid at a low pH. Selective assays for trichomoniasis are also obtained by removing particulate matter from a sample of vaginal fluid to extract a fraction devoid of particles greater than a selected size, and where desired, combining the extracted fraction with any of certain specified hydrolase inhibitors, then testing the fraction for enzymatic hydrolase activity. These qualities of trichomoniasis are the basis for a series of diagnostic tests and test devices that produce results that are detectable by visual and other means with a high degree of accuracy.Type: GrantFiled: October 10, 2002Date of Patent: May 9, 2006Assignee: Quidel CorporationInventors: Paul J. Lawrence, Mark A. Hughes, Aulena Chaudhuri, Terrence J. Andreasen
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Publication number: 20040072280Abstract: The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of these substrates by vaginal fluid at a low pH. Selective assays for trichomoniasis are also obtained by removing particulate matter from a sample of vaginal fluid to extract a fraction devoid of particles greater than a selected size, and where desired, combining the extracted fraction with any of certain specified hydrolase inhibitors, then testing the fraction for enzymatic hydrolase activity. These qualities of trichomoniasis are the basis for a series of diagnostic tests and test devices that produce results that are detectable by visual and other means with a high degree of accuracy.Type: ApplicationFiled: October 10, 2002Publication date: April 15, 2004Applicant: QUIDEL CORPORATIONInventors: Paul J. Lawrence, Mark A. Hughes, Aulena Chaudhuri, Terrence J. Andreasen
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Patent number: 6451607Abstract: A control device serving as a source of control reagent for a solid-phase analytical test device is disclosed. The analytical test device analyzes a biological sample for the presence of an analyte such as an enzyme or other chemical species or a particular pH range, and registers the presence or absence of the analyte as a detectable change in an indicator. The control device contains a control reagent that produces the same indicator change and that can be transferred to the analytical test device by a sample implement such as a wet swab. The control reagent is present on the control device as a dry lamina or combination of laminae. A positive control reagent on a control device in accordance with this invention mimics the action of the analyte once it is transferred to the analytical test device, while a negative control reagent on the control device mimics the action of a sample that lacks the analyte.Type: GrantFiled: March 21, 2000Date of Patent: September 17, 2002Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Robert Pena, Terrence J. Andreasen
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Patent number: 6251621Abstract: Methods of assaying for the presence of enzymatically active hydrolases (i.e., hydrolytic enzymes) in a sample or specimen are disclosed. In particular, a method of detecting candidiasis by assaying for the presence of enzymatically active aspartic protease in a sample is provided. In these methods, a sample or specimen is contacted with a solid support. The solid support with which the sample is contacted has a reporter enzyme (i.e., a signal generating enzyme) immobilized thereon. The reporter enzyme is immobilized on the solid support in a manner such that it is released from the solid support upon action of the enzymatically active hydrolase if the enzymatically active hydrolase is, in fact, present in the sample. The sample after having been contacted with the solid support is combined with an indicator. The indicator is any chemical species which is susceptible to a detectable change, usually a change in color, upon action of the reporter enzyme.Type: GrantFiled: March 17, 1995Date of Patent: June 26, 2001Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Aulena Churhuri, Terrence J. Andreasen
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Patent number: 5585273Abstract: A dry, self-contained test device for assaying for the presence of an enzymatically active hydrolase in a sample is disclosed. The test device combines a reporter enzyme immobilized on a solid support, an indicator, and all other reagents and components necessary to achieve a detectable indication of the presence or absence of the enzymatically active hydrolase in the sample. Preferred devices contain positive and negative controls as well.Type: GrantFiled: November 30, 1994Date of Patent: December 17, 1996Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Aulena Churhuri, Terrence J. Andreasen
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Patent number: 5571684Abstract: The presence of an enzymatically active hydrolase in a fluid sample is detected by contacting the sample with a solid-phase conjugate which is susceptible to cleavage by the hydrolase, and simultaneously or shortly thereafter, contacting the sample with an indicator which undergoes a detectable change upon the action of a reporter group. The reporter group is part of the conjugate and is liberated from it either partly or entirely by the action of the hydrolase. The indicator is susceptible to action by the reporter group only upon decoupling of the reporter group from the remainder of the conjugate, the decoupling occurring either in part or entirely upon action of the hydrolase. Also provided by this invention are various forms of a dry, self-contained test device which contains the conjugate described above plus the indicator and all other reagents and components necessary to achieve a detectable indication of the presence or absence of a catalytically active hydrolase.Type: GrantFiled: January 17, 1995Date of Patent: November 5, 1996Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Terrence J. Andreasen, David R. Shockey
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Patent number: 5416003Abstract: Methods of assaying the presence of enzymatically active hydrolases (i.e., hydrolytic enzymes) in a sample or specimen are disclosed. In particular, a method of detecting candidiasis by assaying for the presence of enzymatically active aspartic protease in a sample is provided. In these methods, a sample or specimen is contacted with a solid support. The solid support with which the sample is contacted has a reporter enzyme (i.e., a signal generating enzyme) immobilized thereon. The reporter enzyme is immobilized on the solid support in a manner such that it is released from the solid support upon action of the enzymatically active hydrolase if the enzymatically active hydrolase is, in fact, present in the sample. The sample after having been contacted with the solid support is combined with an indicator. The indicator is any chemical species which is susceptible to a detectable change, usually a change in color, upon action of the reporter enzyme.Type: GrantFiled: April 14, 1993Date of Patent: May 16, 1995Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Aulena Churhuri, Terrence J. Andreasen