Abstract: In an illustrative embodiment, systems and methods for treatment of nerves present in a wall of a human renal pelvis are described. One system uses a sheath to access a position in or near the renal pelvis via the urinary tract. An effector inserted through the sheath has an uncooled distal region formed with a superelastic wire that supports at least four non-insulated, preferably spherical electrodes distributed along the distal region. The distal region expands within the renal pelvis, and vacuum applied through the sheath at least partially evacuates the renal pelvis to draw opposing walls of the renal pelvis inwards and compress the distal region somewhat from its expanded form, placing the electrodes in intimate contact with different points along the renal pelvic wall. Energy is applied to the electrodes to create discrete lesions at the points of contact of the electrodes.

Abstract: In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: A target peripheral nerve is treated by providing a real-time fluorescent image of a tissue region where the target peripheral nerve has an enhanced appearance in the fluorescent image. A treatment element is advanced from an adjacent body lumen or cavity through the tissue region or externally aimed toward the peripheral nerve while viewing the fluorescent image, and the peripheral nerve is treated using the treatment element.

Abstract: Apparatus, systems, and methods for treating PKD by providing access to a patient's renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Apparatus, systems, and methods for treating PKD by providing access to a patient's renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances to ablate a thin layer of tissue lining at least a portion of the renal pelvis to disrupt renal nerves within the tissue lining of the renal pelvis.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances to ablate a thin layer of tissue lining at least a portion of the renal pelvis to disrupt renal nerves within the tissue lining of the renal pelvis.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.

Abstract: Methods and devices for adhering and securing a tether to a surface are provided. A suction device comprises a base having a top portion and a bottom cavity, a lever, and a flexible suction skirt. The lever has a bottom end, a cam element pivotally coupled to the lever's bottom end and traversing the base's top portion, and at least one cleat along a side of the lever for capturing a tether. The skirt is disposed within the base's bottom cavity and is coupled to the lever's cam element. Closing the lever from a vertical to a horizontal orientation relative to the base causes the cam element to pull the flexible suction skirt to deform the flexible suction skirt, applying suction on the surface and simultaneously moving the cleat horizontally with respect to the base to cinch the captured tether.

Abstract: Systems and methods are provided for attaching a tarpaulin to a truck bed. The tarpaulin is placed over a top opening of the truck bed. A plurality of fastening elements are attached to the tarpaulin. A plurality of tie down members are attached to the sides of the truck bed. A first end of a flexible cord is coupled to a first tie down member. A ratchet is coupled with the first tie down member. The flexible cord is intermittently coupled with the attached plurality of fastening elements and the attached plurality of tie down members. A second end of the flexible cord is passed through the ratchet and tension is applied to the flexible cord to secure the flexible cover to the open enclosure. The ratchet holds the flexible cord in position to maintain the applied tension.

Abstract: Methods, systems and apparatus are provided to modify the operation and function of known truck bed extender systems. The function and operation are modified to provide for a lockable vertical position for a U-shaped frame which otherwise has only forward and rearward horizontal positions. In one embodiment, a bracket is provided which has an anchor hole for receiving a locking pin on the frame. In the second embodiment, a bracket is provided which permits horizontal translation of both the frame pivot pin and an associated anchor hole to permit both raising of the frame and forwardly positioning the frame within the truck bed.

Abstract: A clamp has a handle assembly, a gripping assembly having a pair of jaws that can be opened and closed to grip an element, and a shaft assembly. The shaft assembly has a flexible shaft having a proximal end that is coupled to the handle assembly and a distal end that is coupled to the gripping assembly. The flexible shaft also defines a bore that retains a cable which is operatively coupled to the handle assembly and to the gripping assembly. The shaft assembly also includes a retractable generally rigid covering which can be oriented in a first position where the covering exposes a portion of the flexible shaft, and in a second position where the covering completely covers the flexible shaft.

Abstract: A clamp has a handle assembly, a gripping assembly having a pair of jaws that can be opened and closed to grip an element, and a shaft assembly. The shaft assembly has a flexible shaft having a proximal end that is coupled to the handle assembly and a distal end that is coupled to the gripping assembly. The flexible shaft also defines a bore that retains a cable which is operatively coupled to the handle assembly and to the gripping assembly. The shaft assembly also includes a retractable generally rigid covering which can be oriented in a first position where the covering exposes a portion of the flexible shaft, and in a second position where the covering completely covers the flexible shaft.

Abstract: A medical instrument adapted for disposition a relative to an orifice defined in a body wall or for disposition in a passage in a body is provided. The medical instrument includes an elongate tube portion having a handle disposed at one end thereof, and an expandable section disposed near the other end thereof. The expansion member is expandable to form a seal between the expansion member and a surface of the body wall orifice or the body passage around substantially an entire circumference of the expansion member.