Patents by Inventor Terrence J. CONNOLLY

Terrence J. CONNOLLY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of isoindole compounds and isotopologues thereof
    Patent number: 9434689
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic asymmetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: September 6, 2016
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H. Y. Yong, Chengmin Zhang
  • Asymmetric synthetic processes for the preparation of aminosulfone compounds
    Patent number: 9126906
    Abstract: Processes for synthesizing aminosulfone compounds are provided. The processes provided herein utilize asymmetric reduction reactions, e.g., asymmetric hydrogenation, of protected or unprotected enamine or ketone substrates. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: September 8, 2015
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, William W. Leong
  • PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF
    Publication number: 20150183739
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Application
    Filed: March 9, 2015
    Publication date: July 2, 2015
    Inventors: Terrence J. CONNOLLY, Alexander L. RUCHELMAN, Kelvin H.Y. YONG, Chengmin ZHANG
  • Processes for the preparation of isoindole compounds and isotopologues thereof
    Patent number: 8981117
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: March 17, 2015
    Assignee: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H. Y. Yong, Chengmin Zhang
  • PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF
    Publication number: 20140081032
    Abstract: Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicant: Celgene Corporation
    Inventors: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H.Y. Yong, Chengmin Zhang
  • ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS
    Publication number: 20130217919
    Abstract: Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.
    Type: Application
    Filed: February 20, 2013
    Publication date: August 22, 2013
    Applicant: CELGENE CORPORATION
    Inventors: Terrence J. CONNOLLY, Alexander L. RUCHELMAN, William W. LEONG