Abstract: Compositions and methods are provided for treating diseases associated with CD20, including lymphomas, autoimmune diseases, and transplant rejections. Compositions include anti-CD20 antibodies capable of binding to a human CD20 antigen located on the surface of a human CD20-expressing cell, wherein the antibody has increased complement-dependent cell-mediated cytotoxicity (CDC) that is achieved by having at least one optimized CDR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD20 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD20 antibodies.

Abstract: Compositions and methods are provided for treating diseases associated with CD20, including lymphomas, autoimmune diseases, and transplant rejections. Compositions include anti-CD20 antibodies capable of binding to a human CD20 antigen located on the surface of a human CD20-expressing cell, wherein the antibody has increased complement-dependent cell-mediated cytotoxicity (CDC) that is achieved by having at least one optimized CDR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD20 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD20 antibodies.

Abstract: Compositions and methods are provided for treating diseases associated with CD20, including lymphomas, autoimmune diseases, and transplant rejections. Compositions include anti-CD20 antibodies capable of binding to a human CD20 antigen located on the surface of a human CD20-expressing cell, wherein the antibody has increased complement-dependent cell-mediated cytotoxicity (CDC) that is achieved by having at least one optimized CDR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD20 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD20 antibodies.

Abstract: A printing apparatus and method that provides for severing of prints from receiver media being printed. The receiver media is moved in a process direction past plural printing stations and the printing stations are recording images upon the receiver sheet. While printing is occurring a cutting mechanism having one or more cutting elements is operated to cut the receiver media along a transverse direction to separate a previously printed image on the receiver media from a portion of the receiver media being currently printed. The cutting mechanism includes a clamping member located proximate the one or more cutting elements for stopping movement of the receiver sheet downstream of the clamping mechanism to provide for a substantially square cut relative to the process direction of the receiver media.

Abstract: Disclosed are compositions and methods for preferentially binding hK2 over PSA.

Abstract: A printing apparatus and method that provides for severing of prints from receiver media being printed. The receiver media is moved in a process direction past plural printing stations and the printing stations are recording images upon the receiver sheet. While printing is occurring a cutting mechanism having one or more cutting elements is operated to cut the receiver media along a transverse direction to separate a previously printed image on the receiver media from a portion of the receiver media being currently printed. The cutting mechanism includes a clamping member located proximate the one or more cutting elements for stopping movement of the receiver sheet downstream of the clamping mechanism to provide for a substantially square cut relative to the process direction of the receiver media.

Abstract: A method of equalizing web-stretching caused by web tensioning in a dye transfer printer that is for use with a donor web having a dye transfer area and opposite edge areas alongside the dye transfer area, includes the steps of heating a dye transfer area to effect a dye transfer from the dye transfer area to a dye receiver, and heating the edge areas alongside the dye transfer area less than the dye transfer area is heated to effect the dye transfer, but sufficiently so that the edge areas may be stretched by tension substantially the same as the dye transfer area may be stretched. If the edge areas alongside a dye transfer area being used in the printer are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver in the printer.

Abstract: In a dye transfer printer, a donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in the printer. The longitudinal tension can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head. According to the invention, the resistance of the edge areas relative to the dye transfer areas, to being stretched, is weakened so that the edge areas can be stretched substantially the same as the dye transfer areas. If the edge areas alongside a dye transfer area being used are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver during dye transfer in the printer.

Abstract: A donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in a dye transfer printer, which can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head in the printer. According to the invention, the edge areas are pre-weakened before the donor web is used in the printer to weaken a resistance of the edge areas, relative to the dye transfer areas, to being stretched so that the edge areas can be stretched substantially the same as the dye transfer areas when the donor web is used in the printer. The edge areas can be pre-weakened, for example, by perforating or piercing them to create holes in them, or by slitting or cutting them to create cuts in them.

Abstract: In a dye transfer printer, a donor web having successive dye transfer areas that are used for printing and opposite longitudinal edge areas alongside each one of the dye transfer areas that are not used for printing are wrapped under longitudinal tension about a cylindrical spool core. The dye transfer areas that are wrapped under tension about the spool core are stretched thinner than the two edge areas that are wrapped under tension about the spool core due to their being heated during printing. The spool core is depressible inward at respective portions on which the two edge areas are wrapped under tension and is not depressible at an intermediate portion between the depressible portions on which the thinner transfer areas are wrapped under tension. As a result, a convolution build-up of the edge areas on the spool core will be no more than a convolution build-up of the thinner transfer areas on the spool core.

Abstract: A printer includes a print head for printing from a donor medium to a receiver medium, a platen member for holding the donor medium in a printing relation with the receiver medium at said print head, a pair of steering and drive rollers for feeding the receiver medium from between the steering and drive rollers, and a movable support for the platen member and the steering roller that moves the platen member towards the print head to hold the receiver medium in the printing relation with the donor medium and away from the print head to release the receiver medium from the printing relation with the donor medium and that moves the steering roller to vary a feeding angle at which the receiver medium is fed from between the steering and driver rollers.

Abstract: A dye transfer printer uses a dye donor web that is capable of developing a crease-causing wave-like or ripple distortion across the donor web when the donor web is subjected to a longitudinal tension as it is advanced from a print head, over a web guide, and onto a web take-up spool in the printer. The web guide is positioned to extend across the donor web and is adapted to be bowed to effect a curvature across the donor web in proportion to the longitudinal web tension in order to urge the donor web to spread substantially widthwise to reduce the likelihood of the wave-like or ripple distortion developing across the donor web. If the wave-like or ripple distortion is prevented from developing in a dye transfer area being used, it is unlikely that any creases will be created in the next unused transfer area. Thus, no line artifacts will be printed on a dye receiver during dye transfer in the printer.

Abstract: A printer includes a print head for printing from a donor medium to a receiver medium, a platen member for holding the donor medium in a printing relation with the receiver medium at said print head, a pair of steering and drive rollers for feeding the receiver medium from between the steering and drive rollers, and a movable support for the platen member and the steering roller that moves the platen member towards the print head to hold the receiver medium in the printing relation with the donor medium and away from the print head to release the receiver medium from the printing relation with the donor medium and that moves the steering roller to vary a feeding angle at which the receiver medium is fed from between the steering and driver rollers.

Abstract: A donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in a dye transfer printer, which can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head in the printer. According to the invention, the edge areas are pre-weakened before the donor web is used in the printer to weaken a resistance of the edge areas, relative to the dye transfer areas, to being stretched so that the edge areas can be stretched substantially the same as the dye transfer areas when the donor web is used in the printer. The edge areas can be pre-weakened, for example, by perforating or piercing them to create holes in them, or by slitting or cutting them to create cuts in them.

Abstract: In a dye transfer printer, a donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in the printer. The longitudinal tension can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head. According to the invention, the resistance of the edge areas relative to the dye transfer areas, to being stretched, is weakened so that the edge areas can be stretched substantially the same as the dye transfer areas. If the edge areas alongside a dye transfer area being used are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver during dye transfer in the printer.

Abstract: In a dye transfer printer, a donor web having successive dye transfer areas that are used for printing and opposite longitudinal edge areas alongside each one of the dye transfer areas that are not used for printing are wrapped under longitudinal tension about a cylindrical spool core. The dye transfer areas that are wrapped under tension about the spool core are stretched thinner than the two edge areas that are wrapped under tension about the spool core due to their being heated during printing. The spool core is depressible inward at respective portions on which the two edge areas are wrapped under tension and is not depressible at an intermediate portion between the depressible portions on which the thinner transfer areas are wrapped under tension. As a result, a convolution build-up of the edge areas on the spool core will be no more than a convolution build-up of the thinner transfer areas on the spool core.

Abstract: A dye transfer printer uses a dye donor web that is capable of developing a crease-causing wave-like or ripple distortion across the donor web when the donor web is subjected to a longitudinal tension as it is advanced from a print head, over a web guide, and onto a web take-up spool in the printer. The web guide is positioned to extend across the donor web and is adapted to be bowed to effect a curvature across the donor web in proportion to the longitudinal web tension in order to urge the donor web to spread substantially widthwise to reduce the likelihood of the wave-like or ripple distortion developing across the donor web. If the wave-like or ripple distortion is prevented from developing in a dye transfer area being used, it is unlikely that any creases will be created in the next unused transfer area. Thus, no line artifacts will be printed on a dye receiver during dye transfer in the printer.

Abstract: A method of equalizing web-stretching caused by web tensioning in a dye transfer printer that is for use with a donor web having a dye transfer area and opposite edge areas alongside the dye transfer area, includes the steps of heating a dye transfer area to effect a dye transfer from the dye transfer area to a dye receiver, and heating the edge areas alongside the dye transfer area less than the dye transfer area is heated to effect the dye transfer, but sufficiently so that the edge areas may be stretched by tension substantially the same as the dye transfer area may be stretched. If the edge areas alongside a dye transfer area being used in the printer are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver in the printer.

Abstract: Spring nail (32, 34, 72, 96) for a sheet feeding device (10). The spring nail (32, 34, 72, 96) has a mounting end (36, 74) for attaching to the sheet feeding device (10) and a free end (38, 78) opposite the mounting end (36, 74), the free end (38, 78) being disposed to engage a top sheet (16) of a stack of sheets (14) to be fed and exert a resilient biasing force thereagainst to form a loop or bow in the top sheet (16) for separating the top sheet (16) from the stack (14) when the top sheet (16) is to be removed from the stack (14). The spring nails (32, 34, 72, 96) are preferably positioned for engaging the respective leading corners (28, 30) of the top sheet (16) and each has a spring arm portion (40, 80) between the mounting end (36, 74) and the free end (38, 78) having properties of a spring for resiliently biasing the free end (38, 78) against the top sheet (16).