Patents by Inventor Terrence L. Smalley

Terrence L. Smalley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEROXIREDOXIN 3 INHIBITORS AND METHODS OF USE FOR TREATING CANCER
    Publication number: 20250011316
    Abstract: Provided according to some embodiments is a compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. Pharmaceutical compositions comprising the same and methods of use for treating cancer and inhibiting PRX3 are also provided.
    Type: Application
    Filed: August 22, 2024
    Publication date: January 9, 2025
    Inventors: W. Todd Lowther, Terrence L. Smalley, JR., Kimberly J. Nelson
  • Chemical Compounds
    Publication number: 20220009918
    Abstract: A compound of formula (I), wherein Ar1, R21, R23, R24, R25, R26, R27, A, X, Y and W are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 13, 2022
    Inventors: Rodolfo Cadilla, David Norman Deaton, Andrew L. Larkin, Christie Schulte, Terrence L. Smalley