Patents by Inventor Terrence Michael DOBROWSKY

Terrence Michael DOBROWSKY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROTUBULE DESTABILIZER ADDITIVES TO INCREASE RECOMBINANT VIRAL VECTOR TITERS
    Publication number: 20240101971
    Abstract: The present disclosure pertains to methods and compositions for the production of recombinant viral vectors, e.g., recombinant adeno-associated viruses (rAAVs), using at least one microtubule destabilizing agent described herein.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 28, 2024
    Inventors: Terrence Michael Dobrowsky, Jenny Wang-Yuanzhen Shupe
  • Mammalian cell culture-produced neublastin antibodies
    Patent number: 10717965
    Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: July 21, 2020
    Assignee: Gloriana Therapeutics, Inc.
    Inventors: Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
  • Mammalian cell culture-produced neublastin antibodies
    Patent number: 10669523
    Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 2, 2020
    Assignee: Gloriana Therapeutics, Inc.
    Inventors: Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
  • MAMMALIAN CELL CULTURE-PRODUCED NEUBLASTIN ANTIBODIES
    Publication number: 20190194602
    Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.
    Type: Application
    Filed: December 21, 2018
    Publication date: June 27, 2019
    Inventors: Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
  • MEDIUM SUPPLEMENTS FOR IMPROVED PROCESS PERFORMANCE
    Publication number: 20170029859
    Abstract: The present invention pertains to a cell culture medium comprising dextran sulfate or a mixture of dextran sulfate and ferric citrate, and methods of using thereof. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with dextran sulfate or a mixture of dextran sulfate and ferric citrate.
    Type: Application
    Filed: October 12, 2016
    Publication date: February 2, 2017
    Inventors: Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
  • Medium Supplements for Improved Process Performance
    Publication number: 20150353883
    Abstract: The present invention pertains to a cell culture medium comprising dextran sulfate or a mixture of dextran sulfate and ferric citrate, and methods of using thereof. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with dextran sulfate or a mixture of dextran sulfate and ferric citrate.
    Type: Application
    Filed: January 10, 2014
    Publication date: December 10, 2015
    Inventors: Alan GILBERT, Kyle MCELEARNEY, Terrence Michael DOBROWSKY, Rashmi Rohit KSHIRSAGAR