Patents by Inventor Terrence Michael Hotten

Terrence Michael Hotten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienobenzodiazepine compounds
    Patent number: 6034078
    Abstract: Pharmaceutical compounds of the formula ##STR1## in which R.sup.1 is hydrogen or halo, and R.sup.2 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.3-6 cycloalkyl optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl in which the cycloalkyl group is optionally substituted by 1 to 3 C.sub.1-4 alkyl groups, or optionally substituted phenyl-C.sub.1-4 alkyl; or a salt thereof. Such compounds are useful for treating a disorder of the central nervous system which is associated with the modulation of a 5-HT.sub.3 receptor.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: March 7, 2000
    Assignees: Eli Lilly and Company Limited, Eli Lilly and Company
    Inventors: John Fairhurst, Terrence Michael Hotten, David Edward Tupper, David Taiwai Wong
  • Process for preparing 2-methyl-thieno-benzodiazepine
    Patent number: 6008216
    Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: December 28, 1999
    Assignee: Eli Lilly And Company and Limited
    Inventors: Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
  • Mental disorders
    Patent number: 5817656
    Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-?2,3-b!?1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of mental disorders.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: October 6, 1998
    Assignees: Eli Lilly and Company, Eli Lilly and Company Limited
    Inventors: Charles M. Beasley, Jr., Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
  • Psychoactive substance disorders
    Patent number: 5817657
    Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-?2,3-b!?1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders relating to the use of psychoactive substances.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: October 6, 1998
    Assignees: Eli Lilly and Company, Eli Lilly and Company Limited
    Inventors: Charles M. Beasley, Jr., Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
  • Process and solvate of 2-methyl-thieno-benzodiazepine
    Patent number: 5703232
    Abstract: The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno?2,3-b!?1,5!benzodiazepine (olanzapine) and a process for making such lower alcohol solvates of olanzapine. The invention provides a method for using such solvates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: December 30, 1997
    Assignee: Eli Lilly and Company
    Inventors: Charles A. Bunnell, Terrence Michael Hotten, Samuel D. Larsen, David Edward Tupper
  • Halogenated amino methyl adamantane derivatives
    Patent number: 4061774
    Abstract: Novel 2-substituted-1-methylamino adamantanes of formula: ##STR1## where X is hydroxyl or halogeno, and R.sup.1, R.sup.2 and R.sup.3 are hydrogen or C.sub.1-4 alkyl or R.sup.2 and R.sup.3 together with the nitrogen form a heterocyclic ring, having anti-Parkinsonian activity, pharmaceutical formulations containing the active adamantanes and novel 4-protoadamantane spiro oxirane and 1,2-difunctionalized intermediates useful in the preparation of the final products of the invention.
    Type: Grant
    Filed: April 9, 1975
    Date of Patent: December 6, 1977
    Assignee: Lilly Industries, Limited
    Inventors: Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
  • Process for preparing 2-methyl-thieno-benzodiazepine
    Patent number: RE40033
    Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: January 22, 2008
    Assignee: Eli Lilly and Company
    Inventors: Reba Chakrabarti, Terrence Michael Hotten, David Edward Tupper, Jiban Kumar Chakrabarti