Abstract: Various systems for delivering phase-change particulate ice slurries to targeted areas or organs of a patient are provided. Systems for delivering phase-change particulate ice slurries include a slurry reservoir and a conduit for delivering slurry from the reservoir to the patient. The conduit may include multiple components, including a section of medical tubing, an insertion tip for directing the out flow of slurry to the targeted area, and one or more transition fittings to adapt the tubing to the insertion tip. Interfaces between the various components that form the slurry flow path are configured so that there are no sudden reductions in the cross sectional area of the flow path. Any narrowing of the flow path occurs in a gradual tapered manner. The entire flow path remains substantially free of all obstacles that may tend to trap particles and lead to plugging of the flow path.