Abstract: The invention presents a novel feed formulation and processing optimized for horseshoe crabs in prolonged captivity, with application to myriad species. The formulation is not only sustainable but environmentally advantageous at scale by utilizing fish and poultry processing by-products. The nutrient-rich waste products are enhanced through cold-processed, enzymatic liquefication and fermentation, which preserves proteins and vitamins and thus, nutrient integrity and bioavailability. The formulation is matched to the composition of the horseshoe crab and the flora and fauna of its habitat diet. Feed efficacy can be measured by observed attraction and palatability, as well as parameters including but not limited to cellular integrity and amebocyte reactivity, weight, disease resistance, and carapace metrics.

Abstract: The sustenance of life is driven by recognition of and access to energy sources. This process has remained unchanged over billions of years, guiding cellular nutrition through molecular recognition, akin to the food pyramid. At the atomic or nanoscale, chemotaxis enables organisms to identify ingestible matter and is driven by their need for fuel, rather than from the sustenance itself. Chemotaxis, one of nature's most potent yet invisible organic forces, operates independently of molecular charge dynamics to locate and identify microscopic sustenance. Infectious organisms, such as pathogenic microbes and parasites, depend on chemotactic pathways to locate nutrition across all scales. This invention leverages this phenomenon by “baiting” these pathways with nutritive matter that encapsulates biocidal agents that are harmless to humans but lethal to infectious organisms once ingested.

Abstract: This invention proposes a multifunctional topical composition that integrates halogen-functionalized fullerenes (halo-fullerenes and halo-endofullerenes) and metallic nanoparticles (NPs) to provide comprehensive skin protection and sanitizing, cosmetic enhancement and in some embodiments, treatment for various conditions. Leveraging the atomic scale and physical characteristics of halogenated fullerenes for deeper tissue penetration, the composition can provide antioxidant, antimicrobial, and UV protective benefits to foster cellular integrity, proliferation, and differentiation as healthy tissue. The proposed formulation can penetrate the stratum corneum and diffuse into underlying skin layers due to atomic-scale NPs that can readily deliver active ingredients through the skin via the pores of sweat glands; the lipid matrix of the stratum corneum; and hair follicles, sebaceous glands, and pilosebaceous pores. This composition uses stable inorganic antibacterial agents with a robust safety profile.

Abstract: This invention proposes a multifunctional topical composition that integrates halogen-functionalized fullerenes (halo-fullerenes and halo-endofullerenes) and metallic nanoparticles (NPs) to provide comprehensive skin protection and sanitizing, cosmetic enhancement and in some embodiments, treatment for various conditions. Leveraging the atomic scale and physical characteristics of halogenated fullerenes for deeper tissue penetration, the composition can provide antioxidant, antimicrobial, and UV protective benefits to foster cellular integrity, proliferation, and differentiation as healthy tissue. The proposed formulation can penetrate the stratum corneum and diffuse into underlying skin layers due to atomic-scale NPs that can readily deliver active ingredients through the skin via the pores of sweat glands; the lipid matrix of the stratum corneum; and hair follicles, sebaceous glands, and pilosebaceous pores. This composition uses stable inorganic antibacterial agents with a robust safety profile.

Abstract: This invention relates to a broad-spectrum antimicrobial marine biologic composition for bloodstream infections, derived from smeLAL and optional hemolymph of sustainable aquaculture horseshoe crabs. The formulation serves as an injectable treatment with broad-spectrum antimicrobial activity and an array of therapeutic mechanisms. In one embodiment, subject to clinical studies and characterization of cross-species immunogenicity, the composition may act as a breakthrough antimicrobial—or as a last-resort therapy for critically ill sepsis patients. In an alternative embodiment, the biologically derived antimicrobial agent represents a viable primary therapy with advantages over synthetic antibiotics, including a rapid therapeutic window. Given unmatched efficacy, an adjuvant smeLAL immunoglobulin therapy may be warranted to allow routine use if needed to address cross-species immunogenicity.

Abstract: The present invention represents a breakthrough in addressing the global healthcare challenge of microbial infectious disease diagnosis and management. The invention employs a sustainable, modified, and enhanced protein lysate derived from horseshoe crab aquaculture that allows for rapid, sensitive, and accurate pathogen detection, typing, and determination of antimicrobial susceptibility using biological specimens regardless of opacity, e.g., whole blood. The primary embodiment is highly sensitive to clinically relevant pathogens in complex biological specimens, making it a promising tool for screening, diagnosis and treatment of bloodborne and other microbial infections. The sustainable, modified, and enhanced LAL (smeLAL) substrate and reaction chemistries can provide a cost-effective solution for detecting such pathogens using small volumes of routine hospital and laboratory specimens.

Abstract: This invention proposes a multifunctional topical composition that integrates halogen-functionalized fullerenes and metallic nanoparticles (NPs) to provide comprehensive skin protection and sanitizing, cosmetic enhancement, and in some embodiments, treatment for various conditions. Leveraging the atomic scale and physical characteristics of halogenated fullerenes for deeper tissue dispersion, the composition can provide antioxidant, antimicrobial, and UV protective benefits to foster cellular integrity, proliferation, and differentiation as healthy tissue. The proposed formulation can deliver active ingredients through the pores of sweat glands; the lipid matrix of the stratum corneum; and hair follicles, sebaceous glands, and pilosebaceous pores to then penetrate underlying dermal layers. This composition also uses stable, inorganic antibacterial agents with a robust safety profile.

Abstract: The present invention introduces an ophthalmic solution containing halo-fullerenes. When the spherical fullerene carbon cages are functionalized with halogens, the resulting halo-fullerenes demonstrate sustained antimicrobial activity. Fullerenes are also characterized by unique electron properties that impart antioxidant capabilities as free radical scavengers. Nonetheless, far smaller than ocular tissue cells, halo-fullerenes are biocompatible—and capable of penetrating intricate barriers, like the cornea and conjunctiva, with potential to achieve greater efficacy and symptom relief in chronic dry eye than conventional treatments. With remarkable surface area, halo-fullerenes also allow customization and possess a unique molecular architecture for broader applications. This multifunctional solution thus imparts antimicrobial activity, antioxidative protection, molecular lubrication, and shielding from external irritants while penetrating dense ocular structures.

Abstract: The gut-brain axis, neurobiology and neurotransmission are physiologic systems with known pathways, yet they are rarely leveraged for wellness, notwithstanding extensive literature regarding healthy diets and nutrition. Gastrointestinal (GI) evolution has equipped humans with exceptional plasticity for food abundance or scarcity, while maintaining homeostasis by producing essential neurotransmitters that drive fundamental behaviors, from seeking nourishment to engaging in routine tasks of life. The advent of cheap, abundant, and highly processed foods in the last century, however, has upended the very systems that evolved for survival with a debilitating propensity for obesity in abundance—and malnourishment where access may be limited to a scarce supply of such processed foods, or none at all. In short, a better understanding and application of physiologic signaling and equilibrium is needed in cases of weight management and malnourishment.

Abstract: The gut-brain axis, neurobiology and neurotransmission are physiologic systems with known pathways, yet they are rarely leveraged for wellness, notwithstanding extensive literature regarding healthy diets and nutrition. Gastrointestinal (GI) evolution has equipped humans with exceptional plasticity for food abundance or scarcity, while maintaining homeostasis by producing essential neurotransmitters that drive fundamental behaviors, from seeking nourishment to engaging in routine tasks of life. The advent of cheap, abundant, and highly processed foods in the last century, however, has upended the very systems that evolved for survival with a debilitating propensity for obesity in abundance—and malnourishment where access may be limited to a scarce supply of such processed foods, or none at all. In short, a better understanding and application of physiologic signaling and equilibrium is needed in cases of weight management and malnourishment.

Abstract: Multi-angle radiographic imaging enables 3D visualization of internal surgical targets like solid-tumors, heart vessels, blocked glands or any bodily cavities like fallopian or Eustachian tubes for diagnostics and surgery planning. Those images are dimensionally precise and easily replicated as life-forms with 3D printing for exact modeling. The “negative” aspects of the images are the diseased tissues requiring excision, as in a solid-tumor example. Needle biopsies are routine and can be radiographically guided. Similarly, guided needle delivery of a magnetic surgical fluid containing fullerenes into a target site, such as a solid tumor is less invasive than laparoscopic techniques. Introducing an external magnetic field force can then be used to propel, rotate and maneuver fullerenes into cellular matter or into tissue.

Abstract: The present invention pertains to quantum-scale biocidal particles and chemical reactions that disrupt and eviscerate microbial matter by combining aqueous and dry components. As halo-fullerene activation requires volatile excitation to mix, contact and collide so as to rupture microbial matter, atomic scale chemical reactions impart the requisite movement of engineered halo-fullerenes to destroy bacterial, fungal and viral matter upon contact. The present invention includes two primary mechanisms: an excitation chemistry and biocidal, hydrophobic halo-fullerenes. Upon aqueous exposure, the dry composition initiates a chemical reaction that activates biocidal halo-fullerenes to disrupt biologic surfaces in topical applications. The object of the present invention is a shelf stable, pre-packaged wiping material or dry packet for rehydration with broad spectrum antimicrobial activity.

Abstract: Tissue and organ transplantation success is chiefly dependent on the harvest and preservation techniques employed. Yield and quality enhancements are needed, because qualified patient demand far outpaces donors and ultimately, tissues and organs stored and transported so as to render them in acceptable condition for surgery. In the case of corneal transplants, tissue supplies help 1 out of 70 patients in need despite being among the most successful such procedures today. Transplant success has improved overall with enhanced storage and transport methods that have allowed for greater time and distances to reach patients in need, whether corneas, kidneys, hearts, lungs, livers or other tissues, limbs or cellular materials. While corneal tissues specifically benefit from oxygenation via direct air contact and normal tears in a healthy individual, once donated, the lack of corneal vascularization can uniquely accelerate the depletion of oxygen that occurs upon harvesting of all transplant materials.

Abstract: The present invention provides the methods and composition useful as a contraceptive by preventing motile sperm from reaching a mature ovum, thereby blocking fertilization and preventing pregnancy. The contraceptive is comprised of halogen functionalized fullerene nanoparticles (halo fullerenes) and chemotactic stimulants that act synergistically to divert, incapacitate and ultimately rupture spermatozoa to avert fertilization. When applied vaginally prior to coitus, the suspension is activated by exposure to spermatozoa upon insemination. Notably, non-spermatozoa cells are unaffected by the pH-neutral suspension; however, closer to the same scale, microbes are susceptible to its inherent biocidal properties. Following application and coitus, the contraceptive evacuates naturally, along with seminal and vaginal fluids thereafter.

Abstract: The present invention provides the methods and composition useful as a contraceptive by preventing motile sperm from reaching a mature ovum, thereby blocking fertilization and preventing pregnancy. The contraceptive is comprised of halogen functionalized fullerene nanoparticles (halo fullerenes) and chemotactic stimulants that act synergistically to divert, incapacitate and ultimately rupture spermatozoa to avert fertilization. When applied vaginally prior to coitus, the suspension is activated by exposure to spermatozoa upon insemination. Notably, non-spermatozoa cells are unaffected by the pH-neutral suspension; however, closer to the same scale, microbes are susceptible to its inherent biocidal properties. Following application and coitus, the contraceptive evacuates naturally, along with seminal and vaginal fluids thereafter.

Abstract: The present invention relates to a protective face mask and filtration article, a method for using a protective face mask and filtration article, and a design for manufacturing. In particular, the invention relates to a self-contained, mobile, battery-powered bioactive and filtering breathing appliance that provides broad spectrum antimicrobial and allergic protection via an atomized biocidal agent steam/vapor and a torturous hydrophilic filtration article that sterilizes incoming air and captures debris. To this end, antimicrobial activity and filtration functions leverage a redundancy of means/methods comprised of antimicrobial hydrogen peroxide liquid/vapor/steam and an iodized salt containing hydrophilic filtration article. The present invention is a wearable apparatus that sterilizes incoming air by capturing, neutralizing and destroying airborne pathogens and other particulate matter and pumps sterilized oxygen/air for natural, unlabored breathing by the wearer.

Abstract: The present invention relates to a protective face mask and filtration article, a method for using a protective face mask and filtration article, and a design for manufacturing. In particular, the invention relates to a self-contained, mobile, battery-powered bioactive and filtering breathing appliance that provides broad spectrum antimicrobial and allergic protection via an atomized biocidal agent steam/vapor and a torturous hydrophilic filtration article that sterilizes incoming air and captures debris. To this end, antimicrobial activity and filtration functions leverage a redundancy of means/methods comprised of antimicrobial hydrogen peroxide liquid/vapor/steam and an iodized salt containing hydrophilic filtration article. The present invention is a wearable apparatus that sterilizes incoming air by capturing, neutralizing and destroying airborne pathogens and other particulate matter and pumps sterilized oxygen/air for natural, unlabored breathing by the wearer.

Abstract: The present invention relates to a bioactive or real-time and pathogen killing material comprised of a carbon nanostructure (preferably a fullerene but including other functionalized carbon-based nanostructures) that possess potent broad-spectrum antimicrobial properties. The present invention relates to the utilization of functionalized carbon nanostructures as a bioactive antimicrobial substance that is incorporated into a material, including a textile, fabric, solution, salve, or cream. The preferred embodiment of the present invention is fullerene derivatives that are chemically functionalized on the cage with a halogen element. The present invention pertains to a material that is suitable for barrier garments, accessory garments (shoe covers, masks, facial visors, etc.), textiles (bed sheets, blankets, towels, personal clothing, gowns, surgical drapes, curtains, drapes, pads, etc.), filtration matrices (for use in hemodialysis, hemofiltration, etc.