Patents by Inventor Terry J. Rosen

Terry J. Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 7138418
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: November 21, 2006
    Assignee: Amgen, Inc.
    Inventors: John Flygare, Julio C. Medina, Bei Shan, David L. Clark, Terry J. Rosen
  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 6962929
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 8, 2005
    Assignee: Tularik Inc.
    Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Pentafluorobenzenesulfonamides and analogs
    Publication number: 20030162817
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents.
    Type: Application
    Filed: October 11, 2002
    Publication date: August 28, 2003
    Applicant: Tularik Inc.
    Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 6482860
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: November 19, 2002
    Assignee: Tularik Inc.
    Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Pentafluorobenzenesulfonamides and analogs
    Publication number: 20020143036
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Application
    Filed: October 5, 2001
    Publication date: October 3, 2002
    Applicant: Tularik Inc.
    Inventors: John A Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Benzene compounds as antiproliferative and cholesterol lowering agents
    Patent number: 6388131
    Abstract: The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: May 14, 2002
    Assignee: Tularik, Inc.
    Inventors: Julio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
  • Benzene compounds as antiproliferative and cholesterol lowering agents
    Publication number: 20020013496
    Abstract: The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Application
    Filed: May 31, 2001
    Publication date: January 31, 2002
    Inventors: Julio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 6316484
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: November 13, 2001
    Assignee: Tularik Inc.
    Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Substituted benzene compounds as antiproliferative and cholesterol lowering action
    Patent number: 6284923
    Abstract: The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: September 4, 2001
    Assignee: Tularik INC
    Inventors: Julio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 6121304
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolernia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: September 19, 2000
    Assignee: Tularik Inc
    Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
  • Pentafluorobenzenesulfonamides and analogs
    Patent number: 5880151
    Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: March 9, 1999
    Assignee: Tularik Inc.
    Inventors: Julio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
  • Substituted benzylamino nitrogen containing non-aromatic heterocycles
    Patent number: 5721255
    Abstract: The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: February 24, 1998
    Assignee: Pfizer Inc.
    Inventors: Harry R. Howard, Masami Nakane, Masaya Ikunaka, Kunio Satake, Terry J. Rosen, John A. Lowe, III, Brian T. O'Neill, Fumitaka Ito
  • 3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists
    Patent number: 5688804
    Abstract: The present invention relates to the derivatives of the compound of formula (I), which are useful in the treatment of inflammatory and central nervous system disorders, as well as other diorders ##STR1##
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: November 18, 1997
    Assignee: Pfizer Inc.
    Inventor: Terry J. Rosen
  • Stereoselective preparation of substituted piperidines
    Patent number: 5686615
    Abstract: Novel processes are disclosed for the stereoselective preparation of substituted piperidine derivatives of the formulae ##STR1## wherein R.sup.1 and R.sup.2 are defined as below, useful as substance P receptor antagonists and in treating diseases mediated by an excess of substance P.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: November 11, 1997
    Assignee: Pfizer Inc
    Inventor: Terry J. Rosen
  • Preparation of substituted piperidenes
    Patent number: 5663349
    Abstract: Novel processes are disclosed for the preparation and resolution of substituted piperidines of the formula ##STR1## wherein R.sup.1 and R.sup.2 are defined as below, and related compounds, as well as novel intermediates used in such processes.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: September 2, 1997
    Assignee: Pfizer Inc
    Inventors: Terry J. Rosen, Dennis M. Godek, Sally Gut, Lewin Wint
  • Analogs of oxetanyl purines and pyrimidines
    Patent number: 5597824
    Abstract: A compound of the formula: ##STR1## wherein B is a purin-9-yl group or a heterocyclic isostere of a purin-9-yl group; or a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; A is --CH-- or A--G taken together is --C(.dbd.O)--, --C(.dbd.CH.sub.2)--, --C(OH)(CH.sub.2 OH)-- or ##STR2## and G and D are functional groups; or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: January 28, 1997
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Jacob J. Plattner, Terry J. Rosen
  • Azabicyclo derivatives for treatment of urinary incontinence
    Patent number: 5519033
    Abstract: The present invention relates to a method of treating urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives of azabiaglo and related compounds.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: May 21, 1996
    Assignee: Pfizer Inc.
    Inventors: Terry J. Rosen, Manoj C. Desai, John A. Lowe, III
  • Azabicyclo amides and esters as 5-HT3 receptor antagonists
    Patent number: 5446050
    Abstract: Novel azabicyclo amides and esters as antagonists at the 5-HT.sub.3 receptor and useful as anti-emetic agents.
    Type: Grant
    Filed: May 27, 1992
    Date of Patent: August 29, 1995
    Assignee: Pfizer Inc.
    Inventor: Terry J. Rosen
  • Preparation of substituted piperidines
    Patent number: 5364943
    Abstract: Substituted piperidines and related compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are herein defined are disclosed.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: November 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Terry J. Rosen, Dennis M. Godek, Sally Gut, Lewin Wint
  • Enantiomerically pure aminopyrrolidine compounds
    Patent number: 5359088
    Abstract: A process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine carboxylic acids and quinolone carboxylic acids, and for the preparation of intermediates that are useful in the production of these carboxylic acids.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: October 25, 1994
    Assignee: Abbott Laboratories
    Inventors: Daniel T. Chu, Terry J. Rosen